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本文引用的文献

1
Comparison of different sedatives in children before general anaesthesia for selective surgery: A network meta-analysis.比较不同镇静剂在选择性手术全身麻醉前对儿童的影响:一项网状荟萃分析。
J Clin Pharm Ther. 2022 Oct;47(10):1495-1505. doi: 10.1111/jcpt.13763. Epub 2022 Aug 27.
2
Clonidine Versus Midazolam Premedication and Postoperative Negative Behavioral Changes in Younger Children: A Randomized Controlled Trial.氯胺酮与咪达唑仑在小儿术前用药和术后负性行为变化中的比较:一项随机对照试验。
Anesth Analg. 2022 Aug 1;135(2):307-315. doi: 10.1213/ANE.0000000000005915. Epub 2022 Feb 24.
3
Preoperative anxiety in preschool children: A randomized clinical trial comparing midazolam, clonidine, and dexmedetomidine.学龄前儿童术前焦虑:咪达唑仑、可乐定和右美托咪定的随机临床试验比较。
Paediatr Anaesth. 2021 Nov;31(11):1225-1233. doi: 10.1111/pan.14279. Epub 2021 Aug 26.
4
Clonidine in pediatric anesthesia: the new panacea or a drug still looking for an indication?可乐定在儿科麻醉中的应用:新的万能药还是仍在寻找适应证的药物?
Curr Opin Anaesthesiol. 2019 Jun;32(3):327-333. doi: 10.1097/ACO.0000000000000724.
5
Clonidine exposures in children under 6 (2004-2017): a retrospective study.6 岁以下儿童的可乐定暴露情况(2004-2017 年):一项回顾性研究。
Arch Dis Child. 2019 Mar;104(3):287-291. doi: 10.1136/archdischild-2018-316026. Epub 2018 Nov 13.
6
Incidence of bradycardia at arrival to the operating room after oral or intravenous premedication with clonidine in children.儿童口服或静脉注射可乐定进行术前用药后到达手术室时心动过缓的发生率。
Paediatr Anaesth. 2015 Sep;25(9):956-62. doi: 10.1111/pan.12695. Epub 2015 Jun 17.
7
Toxicity from a clonidine suspension.可乐定混悬液中毒
J Med Toxicol. 2009 Sep;5(3):130-3. doi: 10.1007/BF03161223.
8
Cardiac arrest in a child with cerebral palsy undergoing sevoflurane induction of anesthesia after preoperative clonidine.一名患有脑瘫的儿童在术前使用可乐定后接受七氟醚麻醉诱导时发生心脏骤停。
Paediatr Anaesth. 2007 Mar;17(3):270-2. doi: 10.1111/j.1460-9592.2006.02065.x.
9
Efficacy of oral clonidine premedication in children.口服可乐定术前用药对儿童的疗效。
Anesthesiology. 1993 Nov;79(5):926-31. doi: 10.1097/00000542-199311000-00009.

术前口服可乐定减轻行为障碍儿科患者严重术前焦虑:病例系列报告

Pre-Admission Oral Clonidine to Reduce Severe Pre-Operative Anxiety in Pediatric Patients with Behavioral Disorders: A Case Series.

作者信息

Verdecchia Nicole, Nelson Ryan, White Shante, Cladis Franklyn

机构信息

Department of Anesthesiology, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA.

出版信息

Children (Basel). 2024 Feb 20;11(3):264. doi: 10.3390/children11030264.

DOI:10.3390/children11030264
PMID:38539299
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10969061/
Abstract

Controlling preoperative anxiety is necessary in pediatric patients to avoid adverse effects such as emergence delirium, behavioral problems, post-traumatic stress disorder, anxiety prior to future procedures, and increased analgesic doses in the recovery room. Some patients, especially ones with behavioral issues, have a difficult time arriving at the hospital. Medications given at home can be helpful. We describe a case series of six patients who received pre-admission oral clonidine prior to arrival to the hospital. The patients were all able to enter the hospital without difficulty and the families reported less anxiety and more cooperation subjectively compared with previous experiences. Transient intraoperative hypotension was a side effect of oral clonidine, with no long-term sequelae.

摘要

控制小儿患者的术前焦虑对于避免诸如苏醒期谵妄、行为问题、创伤后应激障碍、未来手术前的焦虑以及恢复室中镇痛剂量增加等不良影响是必要的。一些患者,尤其是有行为问题的患者,很难到达医院。在家服用药物可能会有帮助。我们描述了一组六例患者的病例系列,这些患者在入院前到达医院之前接受了口服可乐定。所有患者都能够顺利进入医院,并且家属主观报告与以往经历相比焦虑减轻,配合度更高。口服可乐定的副作用是术中短暂性低血压,无长期后遗症。