Suppr超能文献

内镜辅助在小儿胆脂瘤手术中对减少残留和复发性疾病的作用。

The Role of Endoscopic Assistance in Surgery for Pediatric Cholesteatoma in Reducing Residual and Recurrent Disease.

作者信息

Nassif Nader, Redaelli de Zinis Luca Oscar

机构信息

Department of Otolaryngology Head and Neck Surgery, Children Hospital, 25100 Brescia, Italy.

Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, Section of Audiology, University of Brescia, 25100 Brescia, Italy.

出版信息

Children (Basel). 2024 Mar 20;11(3):369. doi: 10.3390/children11030369.

Abstract

The primary aim of this study was to evaluate long-term recurrent and residual disease after surgery for acquired cholesteatoma in children according to surgical approach. A total of 71 interventions performed on 67 pediatric patients were included in the study. Canal wall-up tympanomastoidectomy (CWUT) was performed in 31 ears (13 with endoscopic assistance), a transcanal esclusive endoscopic approach (TEEA) was used in 22, and canal wall-down tympanomastoidectomy (CWDT) was performed in 18. Overall, the cholesteatoma relapse rate estimated by the Kaplan-Meier method was 47 ± 6% at 12 years; the recurrent cholesteatoma rate was 28 ± 6% and the residual cholesteatoma rate was 26 ± 5%. The relapse rate according to surgical approach was 33 ± 11% for CWDT, 60 ± 9% for CWUT, and 40 ± 11% for TEEA ( = 0.04). The difference for recurrent disease was no recurrent disease for CWDT, 42 ± 9% for CWUT, and 32 ± 11% for TEEA ( = 0.01). The residual disease rate was significantly reduced with endoscopy: 42 ± 8% without endoscopy vs. 9 ± 5% with ( = 0.003). CWDT can still be considered in primary surgery in case of extensive cholesteatomas and small mastoid with poor pneumatization. TEEA can be recommended for small cholesteatoma not extending to the mastoid to reduce morbidity. Endoscopic assistance seems useful to reduce residual disease in CWUT, whereas it does not have a significant impact on preventing recurrent disease.

摘要

本研究的主要目的是根据手术方式评估儿童获得性胆脂瘤手术后的长期复发和残留疾病情况。该研究纳入了对67例儿科患者进行的71次干预措施。31耳(其中13耳在内镜辅助下)实施了外耳道壁上鼓室乳突切除术(CWUT),22耳采用经耳道单纯内镜入路(TEEA),18耳实施了外耳道壁下鼓室乳突切除术(CWDT)。总体而言,采用Kaplan-Meier法估计的胆脂瘤复发率在12年时为47±6%;复发性胆脂瘤率为28±6%,残留胆脂瘤率为26±5%。根据手术方式,CWDT的复发率为33±11%,CWUT为60±9%,TEEA为40±11%(P = 0.04)。复发性疾病方面的差异为,CWDT无复发性疾病,CWUT为42±9%,TEEA为32±11%(P = 0.01)。内镜检查显著降低了残留疾病率:无内镜检查时为42±8%,有内镜检查时为9±5%(P = 0.003)。对于广泛胆脂瘤且乳突小、气化差的情况,原发性手术仍可考虑采用CWDT。对于未累及乳突的小胆脂瘤,可推荐采用TEEA以降低发病率。内镜辅助似乎有助于减少CWUT中的残留疾病,而对预防复发性疾病没有显著影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8568/10968851/488742123c63/children-11-00369-g001.jpg

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验