多巴胺受体结合可预测抗精神分裂症药物的临床和药理效力。
Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs.
作者信息
Creese I, Burt D R, Snyder S H
出版信息
Science. 1976 Apr 30;192(4238):481-3. doi: 10.1126/science.3854.
PMID:3854
Abstract
Tritiated haloperidol and tritiated dopamine label postsynaptic dopamine receptors in mammalian brain. Clinical potencies of butyrophenones, phenothiazines, and related drugs correlate closely with their ability to inhibit tritiated haloperidol binding. These binding methods provide a simple in vitro means for evaluating new drugs as potential antischizophrenic agents.
摘要
氚标记的氟哌啶醇和氚标记的多巴胺可标记哺乳动物脑中的突触后多巴胺受体。丁酰苯类、吩噻嗪类及相关药物的临床效价与其抑制氚标记氟哌啶醇结合的能力密切相关。这些结合方法为评估新药作为潜在抗精神分裂症药物提供了一种简单的体外手段。
Zotero 插件