Vatasescu Radu, Cojocaru Cosmin, Gondos Viviana, Iorgulescu Corneliu, Bogdan Stefan, Onciul Sebastian, Berruezo Antonio
Department of Cardiothoracic Pathology, Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Cardiology Department, Clinical Emergency Hospital of Bucharest, 014461 Bucharest, Romania.
Biomedicines. 2024 Feb 22;12(3):493. doi: 10.3390/biomedicines12030493.
Prognosis after electrical storm (ES) ablation remains severe, especially in patients with recurrent sustained monomorphic ventricular tachycardia (SMVT) or progressive heart failure (HF). However, single-factor-based prediction is suboptimal and may be refined by more complex algorithms. We sought to evaluate if a novel score MSA-VT (M = moderate/severe mitral regurgitation, S = severe HF at admission, A = atrial fibrillation at admission, VT = inducible SMVT after ablation) may improve prediction of death and recurrences compared to single factors and previous scores (PAINESD, RIVA and I-VT).
A total of 101 consecutive ES ablation patients were retrospectively analyzed over a 32.8-month (IQR 10-68) interval. The MSA-VT score was calculated as the sum of the previously mentioned factors' coefficients based on hazard ratio values in Cox regression analysis. The AUC for death prediction by MSA-VT was 0.84 ( < 0.001), superior to PAINESD (AUC 0.63, = 0.03), RIVA (AUC 0.69, = 0.02) and I-VT (0.56, = 0.3). MSA-VT ≥ 3 was associated with significantly higher mortality during follow-up (52.7%, < 0.001).
Prediction by single factors and previously published scores after ES ablation may be improved by the novel MSA-VT score; however, this requires further external validation in larger samples.
电风暴(ES)消融术后的预后仍然很差,尤其是在复发性持续性单形性室性心动过速(SMVT)或进行性心力衰竭(HF)患者中。然而,基于单一因素的预测并不理想,可能需要通过更复杂的算法来优化。我们试图评估一种新的评分MSA-VT(M = 中重度二尖瓣反流,S = 入院时重度HF,A = 入院时房颤,VT = 消融后可诱发的SMVT)与单一因素及先前的评分(PAINESD、RIVA和I-VT)相比,是否能改善对死亡和复发的预测。
在32.8个月(四分位间距10 - 68个月)的时间间隔内,对101例连续接受ES消融的患者进行回顾性分析。MSA-VT评分是根据Cox回归分析中的风险比值计算上述因素系数之和得出的。MSA-VT预测死亡的曲线下面积(AUC)为0.84(P < 0.001),优于PAINESD(AUC 0.63,P = 0.03)、RIVA(AUC 0.69,P = 0.02)和I-VT(0.56,P = 0.3)。MSA-VT≥3与随访期间显著更高的死亡率相关(52.7%,P < 0.001)。
ES消融术后,新的MSA-VT评分可能会改善单一因素及先前公布评分的预测效果;然而,这需要在更大样本中进行进一步的外部验证。