Claudin 家族蛋白在结直肠癌中的表达。
The Expression of the Claudin Family of Proteins in Colorectal Cancer.
机构信息
Department of Surgery, University of California San Diego, La Jolla, CA 92037, USA.
VA San Diego Healthcare System, La Jolla, CA 92161, USA.
出版信息
Biomolecules. 2024 Feb 24;14(3):272. doi: 10.3390/biom14030272.
Claudins (CLDN1-CLDN24) are a family of tight junction proteins whose dysregulation has been implicated in tumorigeneses of many cancer types. In colorectal cancer (CRC), CLDN1, CLDN2, CLDN4, and CLDN18 have been shown to either be upregulated or aberrantly expressed. In the normal colon, CLDN1 and CLDN3-7 are expressed. Although a few claudins, such as CLDN6 and CLDN7, are expressed in CRC their levels are reduced compared to the normal colon. The present review outlines the expression profiles of claudin proteins in CRC and those that are potential biomarkers for prognostication.
紧密连接蛋白（CLDN1-CLDN24）是紧密连接蛋白家族的成员，其失调与多种癌症类型的肿瘤发生有关。在结直肠癌（CRC）中，CLDN1、CLDN2、CLDN4 和 CLDN18 的表达上调或异常。在正常结肠中，表达 CLDN1 和 CLDN3-7。尽管在 CRC 中也表达少数紧密连接蛋白，如 CLDN6 和 CLDN7，但与正常结肠相比，其水平降低。本综述概述了 CLDN 蛋白在 CRC 中的表达谱以及那些可能作为预后标志物的蛋白。
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