Department of Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Medicina (Kaunas). 2024 Feb 24;60(3):381. doi: 10.3390/medicina60030381.
: The purpose of this study was to investigate whether a new index related to chronic liver disease, the alcoholic liver disease/nonalcoholic fatty liver disease index (ANI) at diagnosis, is associated with all-cause mortality during follow-up in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV). : In this study, we included 270 patients with AAV. ANI was calculated using the following equation: ANI = -58.5 + 0.637 (adjusted mean corpuscular volume) + 3.91 (adjusted aspartate transaminase/alanine transaminase) - 0.406 (body mass index) + 6.35 (if male sex). All-cause mortality was defined as death from any cause during follow-up. : The median age of the 270 patients with AAV was 61.0 years (34.4% male and 66.6% female). The median ANI was significantly higher in deceased patients than in surviving patients. In the receiver operating characteristic curve analysis, ANI at diagnosis exhibited a statistically significant area under the curve for all-cause mortality during follow-up, and its cut-off was determined to be -0.59. Patients with ANI at diagnosis ≥ -0.59 exhibited a significantly higher risk for all-cause mortality and a significantly lower cumulative patient survival rate than those without. In the multivariable Cox analysis, ANI at diagnosis ≥ -0.59, together with age at diagnosis, was independently associated with all-cause mortality. : This study is the first to demonstrate the predictive potential of ANI at diagnosis for all-cause mortality during follow-up in AAV patients without significant chronic liver diseases.
: 本研究旨在探讨一种新的与慢性肝病相关的指标，即酒精性肝病/非酒精性脂肪性肝病指数（ANI）在诊断时是否与抗中性粒细胞胞质抗体相关性血管炎（AAV）患者随访期间的全因死亡率相关。 : 在这项研究中，我们纳入了 270 例 AAV 患者。ANI 采用以下公式计算：ANI = -58.5 + 0.637（调整后的平均红细胞体积）+ 3.91（调整后的天门冬氨酸氨基转移酶/丙氨酸氨基转移酶）- 0.406（体重指数）+ 6.35（如果为男性）。全因死亡率定义为随访期间任何原因导致的死亡。 : 270 例 AAV 患者的中位年龄为 61.0 岁（34.4%为男性，66.6%为女性）。死亡患者的中位 ANI 显著高于存活患者。在受试者工作特征曲线分析中，诊断时的 ANI 对随访期间全因死亡率具有显著的曲线下面积，其截断值为-0.59。诊断时 ANI ≥ -0.59 的患者发生全因死亡的风险显著更高，累积患者生存率显著更低。在多变量 Cox 分析中，诊断时的 ANI ≥ -0.59 与诊断时的年龄一起与全因死亡率独立相关。 : 本研究首次证明，在无明显慢性肝病的 AAV 患者中，诊断时的 ANI 对随访期间的全因死亡率具有预测潜力。
