Teigen Levi, Hamilton Matthew, Hoeg Austin, Chen Lulu, Lopez Sharon, Kabage Amanda, Shah Priyali, Shmidt Eugenia, Vaughn Byron
Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN 55108, USA.
Microbiota Research and Therapeutics, University of Minnesota, Minneapolis, MN 55455, USA.
J Clin Med. 2024 Mar 14;13(6):1663. doi: 10.3390/jcm13061663.
Crohn's disease (CD) is often treated with either exclusive or supplemental enteral nutrition (EN) in pediatrics, but adult practice guidelines primarily focus on medications. Here, we demonstrate the feasibility of a 4-week semi-elemental-formula-based oral nutrition delivery program for managing adult CD ( = 4). Patients consumed ~66% of calories from the formula, a finding that might provide an improved calorie target for future trials. We identified as the only differentially abundant genus, distinguishing post-intervention samples from pre-intervention samples. Findings from this pilot trial demonstrate the feasibility of a partial enteral nutrition protocol in adult CD management and contribute to the growing body of literature on the potential role of EN therapy in adults with CD.
克罗恩病（CD）在儿科通常采用全肠内营养或补充肠内营养（EN）进行治疗，但成人实践指南主要侧重于药物治疗。在此，我们证明了一项基于半要素配方的为期4周的口服营养输送计划用于管理成人CD（n = 4）的可行性。患者从该配方中摄入了约66%的热量，这一发现可能为未来试验提供一个更高的热量目标。我们确定[具体内容缺失]为唯一差异丰富的属，可将干预后样本与干预前样本区分开来。这项试点试验的结果证明了部分肠内营养方案在成人CD管理中的可行性，并为关于EN治疗在成人CD患者中潜在作用的不断增长的文献做出了贡献。
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