Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Department of Dermatology and Venereology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Int J Mol Sci. 2024 Mar 20;25(6):3486. doi: 10.3390/ijms25063486.
This study investigates the roles of mucosal-associated invariant T (MAIT) cells and Vα7.2/CD161 T cells in skin diseases, focusing on atopic dermatitis. MAIT cells, crucial for bridging innate and adaptive immunity, were analyzed alongside Vα7.2/CD161 T cells in peripheral blood samples from 14 atopic dermatitis patients and 10 healthy controls. Flow cytometry and machine learning algorithms were employed for a comprehensive analysis. The results indicate a significant decrease in MAIT cells and CD69 subsets in atopic dermatitis, coupled with elevated CD38 and polyfunctional MAIT cells producing TNFα and Granzyme B (TNFα/GzB). Vα7.2/CD161 T cells in atopic dermatitis exhibited a decrease in CD8 and IFNγ-producing subsets but an increase in CD38 activated and IL-22-producing subsets. These results highlight the distinctive features of MAIT cells and Vα7.2/CD161 T cells and their different roles in the pathogenesis of atopic dermatitis and provide insights into their potential roles in immune-mediated skin diseases.
本研究探讨了黏膜相关不变 T（MAIT）细胞和 Vα7.2/CD161 T 细胞在皮肤疾病中的作用，重点关注特应性皮炎。在 14 名特应性皮炎患者和 10 名健康对照者的外周血样本中，分析了 MAIT 细胞和 Vα7.2/CD161 T 细胞。采用流式细胞术和机器学习算法进行全面分析。结果表明，特应性皮炎患者 MAIT 细胞和 CD69 亚群显著减少，同时 CD38 和产生 TNFα 和 Granzyme B（TNFα/GzB）的多功能 MAIT 细胞增多。特应性皮炎患者中的 Vα7.2/CD161 T 细胞 CD8 和 IFNγ 产生亚群减少，而 CD38 激活和 IL-22 产生亚群增加。这些结果突出了 MAIT 细胞和 Vα7.2/CD161 T 细胞的独特特征及其在特应性皮炎发病机制中的不同作用，并为它们在免疫介导的皮肤疾病中的潜在作用提供了新的见解。
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