Czyż Anna, Zakrzewska-Sito Alicja, Kuczyńska Julita
Chair of Analytical Chemistry, Faculty of Chemistry, Warsaw University of Technology, 00-664 Warsaw, Poland.
Department of Pharmacology, Institute of Psychiatry and Neurology, Sobieskiego Street 9, 02-957 Warsaw, Poland.
Pharmaceuticals (Basel). 2024 Mar 21;17(3):403. doi: 10.3390/ph17030403.
Schizophrenia is a serious mental disorder that significantly affects the social and professional life of patients, causing distortion of reality and loss of identity and cognitive abilities. Psychopharmacological treatment is an integral part of modern psychiatry, and the introduction of new "atypical" antipsychotic drugs has brought significant progress in the treatment of this disorder. One of these drugs is olanzapine, which has an effective effect on the productive symptoms of schizophrenia while having an almost minimal potential to cause extrapyramidal syndrome. However, its effectiveness is confronted with frequent side effects, referred to as "metabolic disorders". Therefore, to ensure the effectiveness of treatment and to minimize the side effects caused by olanzapine, it is recommended to monitor the drug level during therapy. This article reviews the bioanalytical methodologies that enable efficient extraction and sensitive analysis of olanzapine. We considered the advantages and disadvantages of different sample pretreatment methods, including traditional and novel strategies. The analytical conditions required for the separation and detection of olanzapine and its metabolites were analyzed using chromatographic methods combined with various detectors.
精神分裂症是一种严重的精神障碍，严重影响患者的社交和职业生活，导致现实扭曲、身份认同丧失以及认知能力下降。精神药理学治疗是现代精神病学的一个组成部分，新型“非典型”抗精神病药物的引入在该疾病的治疗方面取得了重大进展。其中一种药物是奥氮平，它对精神分裂症的阳性症状有显著疗效，同时引起锥体外系综合征的可能性几乎极小。然而，其有效性面临着频繁出现的副作用，即所谓的“代谢紊乱”。因此，为确保治疗效果并尽量减少奥氮平引起的副作用，建议在治疗期间监测药物水平。本文综述了能够有效提取和灵敏分析奥氮平的生物分析方法。我们考虑了不同样品预处理方法的优缺点，包括传统方法和新策略。使用色谱方法结合各种检测器分析了分离和检测奥氮平及其代谢物所需的分析条件。
