Hantoushzadeh Sedigheh, Behzadian Arezoo, Mehdi Hasheminejad Mohammad, Hasheminejad Faezeh, Helal Birjandi Alireza, Akbari Mojtaba, Ghaemi Marjan
Vali-E-Asr Reproductive Health Research Center, Family Health Research Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
Department of Perinatology, Vali-E-Asr Hospital, Imam Khomeini Hospital Complex, Tehran, Iran.
Int J Reprod Biomed. 2024 Feb 23;22(1):69-80. doi: 10.18502/ijrm.v22i1.15244. eCollection 2024 Jan.
Pre-eclampsia (PE) is a multiorgan disorder that affects 2-5% of all pregnant women. Present recommendations for when to start aspirin in high-risk women are after 11 wk of gestation.
We present a protocol to investigate the effectiveness of aspirin use from early pregnancy, which is a randomized controlled trial to assess whether prescribed low-dose aspirin from early pregnancy reduces the prevalence of early and late-onset PE. Additionally, to compare the effectiveness of aspirin administration before and after 11 wk in reducing the occurrence of PE?
All pregnancies at risk of PE, according to demographic and midwifery history, who are referred to the Maternal-Fetal Clinic of Tehran University hospital, Tehran, Iran were invited to take part in the trial. The outcomes of pregnancy and newborns will be gathered and analyzed. The first registration for the pilot study was in January 2023, and the participants were recognized as high-risk for PE. In addition, enrollment in the main study will begin as of October 2023.
子痫前期（PE）是一种多器官疾病，影响2%至5%的孕妇。目前对于高危女性何时开始使用阿司匹林的建议是在妊娠11周后。
我们提出一项方案，以研究从妊娠早期开始使用阿司匹林的有效性，这是一项随机对照试验，旨在评估妊娠早期开具的低剂量阿司匹林是否能降低早发型和晚发型PE的患病率。此外，比较在11周之前和之后服用阿司匹林在降低PE发生率方面的有效性。
根据人口统计学和助产史，所有有PE风险的孕妇，被转诊至伊朗德黑兰德黑兰大学医院母胎诊所，受邀参加该试验。将收集并分析妊娠和新生儿的结局。试点研究的首次登记于2023年1月进行，参与者被认定为PE高危人群。此外，主要研究将于2023年10月开始招募。
