新型冠状病毒肺炎的临床严重程度与高分辨率CT严重程度评分：二者是否存在关联？
Clinical severity and high-resolution CT severity score in COVID-19: Is there an association.
作者信息
Ahmed Raja Mobeen, Toori Kaleem Ullah, Qureshi Muhammad Arsalan
机构信息
Raja Mobeen Ahmed, MBBS. Department of Medicine, KRL Hospital, Islamabad, Pakistan.
Kaleem Ullah Toori, FRCP. Department of Medicine, KRL Hospital, Islamabad, Pakistan.
出版信息
Pak J Med Sci. 2024 Mar-Apr;40(4):637-641. doi: 10.12669/pjms.40.4.7919.
OBJECTIVES
To identify a correlation between the clinical parameters and CT chest severity score in COVID-19.
METHODS
A total of 205 RT-PCR positive patients were included in this descriptive cross-sectional study with convenience sampling from November 2020 to June 2021 in KRL Hospital. The study population was stratified in disease severity as per the WHO's guidelines. Clinical and radiological characteristics were compared in survivors and non survivors to draw conclusion.
RESULTS
The mean age was 57 years and the majority of the patients 57% were male. Overall mortality was 22% and the mean CT severity score was 18. Non survivors were more tachypneic, hypoxic, had a higher CT chest severity score, higher clinical severity, more comorbid condition and higher TLC, D-Dimers, LDH, CRP, NLR. Raised CT severity score showed a conclusive correlation with greater disease severity. One way ANOVA showed a significant difference between mean CT severity score amongst different disease categories.
CONCLUSION
Higher CT severity score corresponds to a higher clinical severity and higher chances of mortality.
目的
确定新型冠状病毒肺炎（COVID-19）临床参数与胸部CT严重程度评分之间的相关性。
方法
本描述性横断面研究采用便利抽样法，纳入了2020年11月至2021年6月在卡拉奇真纳医院（KRL Hospital）的205例逆转录聚合酶链反应（RT-PCR）阳性患者。根据世界卫生组织（WHO）的指南，将研究人群按疾病严重程度进行分层。比较幸存者和非幸存者的临床和影像学特征以得出结论。
结果
平均年龄为57岁，大多数患者（57%）为男性。总体死亡率为22%，平均CT严重程度评分为18分。非幸存者呼吸急促、缺氧情况更严重，胸部CT严重程度评分更高，临床严重程度更高，合并症更多，总淋巴细胞计数（TLC）、D-二聚体、乳酸脱氢酶（LDH）、C反应蛋白（CRP）、中性粒细胞与淋巴细胞比值（NLR）更高。CT严重程度评分升高与更高的疾病严重程度呈明确相关性。单因素方差分析显示不同疾病类别之间的平均CT严重程度评分存在显著差异。
结论
更高的CT严重程度评分对应更高的临床严重程度和更高的死亡几率。
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