Pulmonary and Critical Care Medicine, Affiliated Hospital of Putian University, Putian, China.
Department of Clinical Medicine, Fujian Medical University, Fuzhou, Fujian, China.
Int J Clin Pract. 2021 Dec;75(12):e14907. doi: 10.1111/ijcp.14907. Epub 2021 Oct 8.
The association between computed tomography (CT) and clinical severity of COVID-19 has been demonstrated. However, there are few studies on CT and laboratory indicators in patients in COVID-19. Our aim was to explore the correlation between chest CT images and laboratory indicators of patients with COVID-19 pneumonia.
This was a retrospective study of patients with COVID-19 diagnosed and treated at the Affiliated Hospital of Putian University from 24 January 2020 to 6 March 2020. The correlation test between first chest CT score and blood cell analysis, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), blood biochemistry and T lymphocyte subsets (T-Ls) was investigated.
Among the 56 patients, there were 36 (64.3%) males and 20 (35.7%) females. The mean age of the patients was 46.54 ± 15.82 (range, 15-86) years. The CT score in the moderate group was higher than in the mild group (5.06 ± 0.77 vs 1.87 ± 0.88, P < .05), and higher in the severe group than in the moderate and mild groups (10.71 ± 4.21, P < .05). In addition, the ESR was significantly higher in the severe group than mild group (32.00 (26.04, 58.24) vs 11.00 (7.84, 24.70) mm/h, P < .05). The CD3, CD4, CD8 and CD4/CD8 cells were not different (all P > .05). The CT scores of all patients correlated positively with CRP, LDH and ESR (all P < .01).
The chest CT characteristics of patients with COVID-19 correlated positively with CRP, ESR and LDH, which may use one of the indicators for the assessment of disease severity.
已经证明计算机断层扫描（CT）与 COVID-19 的临床严重程度之间存在关联。然而，关于 COVID-19 患者的 CT 和实验室指标的研究较少。我们的目的是探讨 COVID-19 肺炎患者的胸部 CT 图像与实验室指标之间的相关性。
这是一项回顾性研究，纳入了 2020 年 1 月 24 日至 2020 年 3 月 6 日在莆田学院附属医院就诊的 COVID-19 患者。对首次胸部 CT 评分与血细胞分析、C 反应蛋白（CRP）、红细胞沉降率（ESR）、血液生化和 T 淋巴细胞亚群（T-Ls）之间的相关性进行了检验。
56 例患者中，男性 36 例（64.3%），女性 20 例（35.7%）。患者的平均年龄为 46.54±15.82 岁（15-86 岁）。中重度组的 CT 评分高于轻度组（5.06±0.77 比 1.87±0.88，P<.05），重度组高于中重度和轻度组（10.71±4.21，P<.05）。此外，重度组的 ESR 明显高于轻度组（32.00（26.04，58.24）比 11.00（7.84，24.70）mm/h，P<.05）。CD3、CD4、CD8 和 CD4/CD8 细胞无差异（均 P>.05）。所有患者的 CT 评分与 CRP、LDH 和 ESR 呈正相关（均 P<.01）。
COVID-19 患者的胸部 CT 特征与 CRP、ESR 和 LDH 呈正相关，这可能是评估疾病严重程度的指标之一。
