Hamada Satoshi, Togawa Jumpei, Sunadome Hironobu, Nagasaki Tadao, Takahashi Naomi, Hirai Toyohiro, Sato Susumu
Department of Advanced Medicine for Respiratory Failure, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Department of Respiratory Care and Sleep Control Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Sleep Sci. 2024 Feb 15;17(1):e37-e44. doi: 10.1055/s-0043-1776741. eCollection 2024 Mar.
Sleep restfulness is closely associated with mortality. Thus, it is an important sleep-related symptom in the general population. However, it is rarely evaluated in patients with obstructive sleep apnea (OSA) syndrome. The present study examined the importance of sleep restfulness in patients with OSA receiving continuous positive airway pressure (CPAP) therapy. We administered sleep-related questionnaires, which included items such as subjective sleep duration and sleep restfulness, to 775 patients with OSA receiving CPAP therapy. Sleep restfulness was rated using a 5-point Likert-type scale, with the score of 5 indicating restfulness. Good adherence to CPAP therapy was defined as the use of CPAP therapy for at least 4 h per night in 70% of nights. We excluded 105 patients with lacking data. Thus, 670 patients were finally examined. In total, 29 (4.3%), 124 (18.5%), 139 (20.8%), 235 (35.1%), and 143 (14.3%) patients answered restless (1), somewhat restless (2), neither (3), somewhat restful (4), and restful (5) respectively. A total of 467 (69.7%) patients had good adherence to CPAP therapy. Multivariate logistic regression analysis showed that sleep restfulness was independently and positively associated with subjective sleep duration (≥ 7 hours) and good adherence to CPAP therapy. Sleep restfulness was associated with subjective sleep duration and good adherence to CPAP therapy in patients with OSA. Favorable outcomes are significantly correlated with good adherence to CPAP therapy. Thus, sleep restfulness can be an indicator of a subtype that has favorable outcomes in patients after CPAP therapy.
睡眠安稳与死亡率密切相关。因此，它是普通人群中一种重要的与睡眠相关的症状。然而，在阻塞性睡眠呼吸暂停（OSA）综合征患者中很少对其进行评估。本研究探讨了睡眠安稳在接受持续气道正压通气（CPAP）治疗的OSA患者中的重要性。
我们向775例接受CPAP治疗的OSA患者发放了与睡眠相关的问卷，其中包括主观睡眠时间和睡眠安稳程度等项目。睡眠安稳程度采用5分李克特量表进行评分，5分表示安稳。CPAP治疗的良好依从性定义为70%的夜晚每晚使用CPAP治疗至少4小时。
我们排除了105例数据缺失的患者。最终对670例患者进行了检查。总共有29例（4.3%）、124例（18.5%）、139例（20.8%）、235例（35.1%）和143例（14.3%）患者分别回答不安稳（1分）、有点不安稳（2分）、既不（3分）、有点安稳（4分）和安稳（5分）。共有467例（69.7%）患者对CPAP治疗依从性良好。多因素逻辑回归分析表明，睡眠安稳程度与主观睡眠时间（≥7小时）和CPAP治疗的良好依从性独立且呈正相关。
睡眠安稳程度与OSA患者的主观睡眠时间和CPAP治疗的良好依从性相关。良好的治疗效果与CPAP治疗的良好依从性显著相关。因此，睡眠安稳程度可以作为CPAP治疗后患者预后良好亚型的一个指标。
