Liu Anli A, Barr William B
Langone Medical Center, New York University, New York, NY, United States.
Department of Neurology, School of Medicine, New York University, New York, NY, United States.
Front Neurol. 2024 Mar 13;14:1260523. doi: 10.3389/fneur.2023.1260523. eCollection 2023.
Due to shared hippocampal dysfunction, patients with Alzheimer's dementia and late-onset epilepsy (LOE) report memory decline. Multiple studies have described the epidemiological, pathological, neurophysiological, and behavioral overlap between Alzheimer's Disease and LOE, implying a bi-directional relationship. We describe the neurobiological decline occurring at different spatial in AD and LOE patients, which may explain why their phenotypes overlap and differ. We provide suggestions for clinical recognition of dual presentation and novel approaches for behavioral testing that reflect an "inside-out," or biologically-based approach to testing memory. New memory and language assessments could detect-and treat-memory impairment in AD and LOE at an earlier, actionable stage.
由于海马体功能障碍，阿尔茨海默病性痴呆和晚发性癫痫（LOE）患者均出现记忆衰退。多项研究描述了阿尔茨海默病与LOE在流行病学、病理学、神经生理学和行为学方面的重叠，这意味着两者之间存在双向关系。我们描述了阿尔茨海默病患者和LOE患者在不同空间发生的神经生物学衰退，这可能解释了为什么他们的表型既有重叠又有差异。我们为双重症状的临床识别提供建议，并为行为测试提供新方法，这些方法反映了一种“由内而外”或基于生物学的记忆测试方法。新的记忆和语言评估可以在更早的可采取行动阶段检测并治疗阿尔茨海默病和LOE中的记忆障碍。
