• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

基因表达谱指导的胃癌腹膜转移个体化腹腔内化疗

Gene Expression Profile-Guided Personalized Intraperitoneal Chemotherapy for Gastric Cancer Peritoneal Carcinomatosis.

作者信息

Markovich Vitaly A, Tuzikov Sergey A, Rodionov Evgeny O, Popova Natalia O, Tsyganov Matvey M, Miller Sergey V, Podolko Danil V, Tsydenova Irina A, Ibragimova Marina K, Litviakov Nikolai V

机构信息

Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russia.

Siberian State Medical University, Tomsk, Russia.

出版信息

World J Oncol. 2024 Apr;15(2):298-308. doi: 10.14740/wjon1578. Epub 2024 Mar 21.

DOI:10.14740/wjon1578
PMID:38545480
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10965258/
Abstract

BACKGROUND

Peritoneal carcinomatosis (PC) is one of the most unfavorable sites of metastasis for malignant tumors of various localizations, especially gastric cancer (GC). According to the literature, synchronous PC in GC is common in 15-52% of patients. The purpose of this study was to examine the long-term results using personalized systemic and intraperitoneal chemotherapy as part of the combined treatment of stomach cancer presenting with synchronous PC.

METHODS

Cytoreductive surgical treatment was performed for 70 patients at the first stage. The control group (n = 35) received standard postoperative chemotherapy according to the FOLFOX scheme. Personalized postoperative systemic and intraperitoneal chemotherapy was administered in the basic group (n = 35), based on the expression levels of the eight genes in the primary tumor, lymph node, and peritoneal metastases.

RESULTS

The median progression-free survival was 14.9 months in the basic group, and in the control group it was 11.2 months (P < 0.001). The median life expectancy in the basic group was 16.8 (13.7 - 18.8) months, in the control group it was 12.5 (11.3 - 13.1) months (P < 0.001).

CONCLUSIONS

Developing algorithms of personalized systemic and intraperitoneal chemotherapy in patients with GC with synchronous carcinomatosis, based on the analysis of molecular genetic characteristics of the tumor and metastases, allows to improve the long-term results of combined treatment.

摘要

背景

腹膜癌病（PC）是各种部位恶性肿瘤最不利的转移部位之一，尤其是胃癌（GC）。根据文献，GC患者中同步性PC的发生率为15%-52%。本研究的目的是检验采用个性化全身和腹腔内化疗作为同步性PC胃癌综合治疗一部分的长期疗效。

方法

70例患者在第一阶段接受了减瘤手术治疗。对照组（n = 35）接受根据FOLFOX方案的标准术后化疗。基础组（n = 35）根据原发肿瘤、淋巴结和腹膜转移灶中8个基因的表达水平进行个性化术后全身和腹腔内化疗。

结果

基础组的无进展生存期中位数为14.9个月，对照组为11.2个月（P < 0.001）。基础组的中位预期寿命为16.8（13.7 - 18.8）个月，对照组为12.5（11.3 - 13.1）个月（P < 0.001）。

结论

基于肿瘤和转移灶分子遗传特征分析，为同步性癌病的GC患者制定个性化全身和腹腔内化疗算法，可改善综合治疗的长期疗效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c16/10965258/4122706605c7/wjon-15-298-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c16/10965258/89217e672b72/wjon-15-298-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c16/10965258/bf544def860b/wjon-15-298-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c16/10965258/ee063561d494/wjon-15-298-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c16/10965258/e8002d0c84c4/wjon-15-298-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c16/10965258/4122706605c7/wjon-15-298-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c16/10965258/89217e672b72/wjon-15-298-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c16/10965258/bf544def860b/wjon-15-298-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c16/10965258/ee063561d494/wjon-15-298-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c16/10965258/e8002d0c84c4/wjon-15-298-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c16/10965258/4122706605c7/wjon-15-298-g005.jpg

相似文献

1
Gene Expression Profile-Guided Personalized Intraperitoneal Chemotherapy for Gastric Cancer Peritoneal Carcinomatosis.基因表达谱指导的胃癌腹膜转移个体化腹腔内化疗
World J Oncol. 2024 Apr;15(2):298-308. doi: 10.14740/wjon1578. Epub 2024 Mar 21.
2
Treatment of Peritoneal Dissemination in Stomach Cancer Patients With Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC): Rationale and Design of the PERISCOPE Study.胃癌患者腹膜播散的细胞减灭术和腹腔内热灌注化疗（HIPEC）治疗：PERISCOPE研究的原理与设计
JMIR Res Protoc. 2017 Jul 13;6(7):e136. doi: 10.2196/resprot.7790.
3
Combined Cytoreductive Surgery and Early Postoperative Intraperitoneal Chemotherapy for Peritoneal Carcinomatosis of Gastric Cancer.联合细胞减灭术和术后早期腹腔内化疗治疗胃癌腹膜转移。
Cancer Res Treat. 2003 Dec;35(6):507-13. doi: 10.4143/crt.2003.35.6.507.
4
[Efficacy of 1 384 cases of peritoneal carcinomatosis underwent cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy].1384例腹膜癌病患者接受细胞减灭术加腹腔内热灌注化疗的疗效
Zhonghua Wei Chang Wai Ke Za Zhi. 2021 Mar 25;24(3):230-239. doi: 10.3760/cma.j.cn.441530-20201110-00603.
5
Timing of Systemic Chemotherapy in Patients With Colorectal Peritoneal Carcinomatosis Treated With Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy.接受细胞减灭术和腹腔内热灌注化疗的结直肠癌腹膜转移患者全身化疗的时机
Dis Colon Rectum. 2017 May;60(5):477-487. doi: 10.1097/DCR.0000000000000774.
6
Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy with lobaplatin and docetaxel to treat synchronous peritoneal carcinomatosis from gastric cancer: Results from a Chinese center.细胞减灭术联合洛铂与多西他赛腹腔热灌注化疗治疗胃癌同步性腹膜转移癌：来自中国一家中心的结果
Eur J Surg Oncol. 2016 Jul;42(7):1024-34. doi: 10.1016/j.ejso.2016.04.053. Epub 2016 May 3.
7
Cytoreductive surgery and hyperthermic intraperitoneal chemoperfusion versus systemic chemotherapy alone for colorectal peritoneal carcinomatosis.细胞减灭术和腹腔内热灌注化疗联合全身化疗与单纯全身化疗治疗结直肠腹膜转移癌的比较。
Cancer. 2010 Aug 15;116(16):3756-62. doi: 10.1002/cncr.25116.
8
Curative cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy in patients with peritoneal carcinomatosis and synchronous resectable liver metastases arising from colorectal cancer.对患有腹膜癌病和同时存在可切除的结直肠癌肝转移的患者，先进行根治性细胞减灭术，然后进行腹腔内热灌注化疗。
Eur J Surg Oncol. 2017 Jan;43(1):150-158. doi: 10.1016/j.ejso.2016.09.010. Epub 2016 Oct 7.
9
Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with gastric cancer and peritoneal carcinomatosis.细胞减灭术联合腹腔热灌注化疗（HIPEC）治疗胃癌合并腹膜转移患者。
Eur J Surg Oncol. 2018 Nov;44(11):1805-1810. doi: 10.1016/j.ejso.2018.06.036. Epub 2018 Jul 26.
10
Cytoreduction (CRS) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC)肿瘤细胞减灭术（CRS）与腹腔热灌注化疗（HIPEC）

引用本文的文献

1
Risk Scoring System to Predict Mortality in Gastric Cancer with Peritoneal Carcinomatosis.胃癌伴腹膜转移患者死亡风险评分系统
Med Sci (Basel). 2024 Jun 9;12(2):30. doi: 10.3390/medsci12020030.

本文引用的文献

1
Recent trend in gastric cancer treatment in the USA.美国胃癌治疗的近期趋势。
J Cancer Metastasis Treat. 2018 Apr 4;4. doi: 10.20517/2394-4722.2017.74. Epub 2018 Apr 26.
2
Prevention and Treatment of Peritoneal Metastases from Gastric Cancer.胃癌腹膜转移的防治
J Clin Med. 2021 Apr 28;10(9):1899. doi: 10.3390/jcm10091899.
3
Prognostic significance of ERCC1, RRM1, TOP1, TOP2A, TYMS, TUBB3, GSTP1 AND BRCA1 mRNA expressions in patients with non-small-cell lung cancer receiving a platinum-based chemotherapy.
在接受铂类化疗的非小细胞肺癌患者中，ERCC1、RRM1、TOP1、TOP2A、TYMS、TUBB3、GSTP1 和 BRCA1 mRNA 表达的预后意义。
J BUON. 2020 Jul-Aug;25(4):1728-1736.
4
Advances with pharmacotherapy for peritoneal metastasis.腹腔转移的药物治疗进展。
Expert Opin Pharmacother. 2020 Nov;21(16):2057-2066. doi: 10.1080/14656566.2020.1793957. Epub 2020 Aug 12.
5
Recent Advances in Intra-peritoneal Chemotherapy for Gastric Cancer.胃癌腹腔内化疗的最新进展
J Gastric Cancer. 2020 Jun;20(2):115-126. doi: 10.5230/jgc.2020.20.e15. Epub 2020 Apr 10.
6
Intraperitoneal chemotherapy for peritoneal metastases: an expert opinion.腹腔内化疗治疗腹膜转移：专家意见。
Expert Opin Drug Deliv. 2020 Apr;17(4):511-522. doi: 10.1080/17425247.2020.1736551. Epub 2020 Mar 18.
7
Pressurized intraperitoneal aerosol chemotherapy (PIPAC) of peritoneal metastasis from gastric cancer: a descriptive cohort study.胃癌腹膜转移的腹腔内加压气溶胶化疗（PIPAC）：一项描述性队列研究。
Clin Exp Metastasis. 2020 Apr;37(2):325-332. doi: 10.1007/s10585-020-10023-5. Epub 2020 Jan 30.
8
Issues on peritoneal metastasis of gastric cancer: an update.胃癌腹膜转移相关问题：最新研究进展。
World J Surg Oncol. 2019 Dec 11;17(1):215. doi: 10.1186/s12957-019-1761-y.
9
Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Gastric Cancer.胃癌的细胞减灭术及腹腔热灌注化疗
Cancers (Basel). 2019 Oct 26;11(11):1662. doi: 10.3390/cancers11111662.
10
Gastric Cancer Peritoneal Carcinomatosis Risk Score.胃癌腹膜转移危险评分
Ann Surg Oncol. 2020 Jan;27(1):240-247. doi: 10.1245/s10434-019-07624-0. Epub 2019 Jul 25.