Agreement between PSMA-RADS and E-PSMA systems in classifying [F]PSMA-1007 PET/CT lesions among prostate cancer patients: exploring the correlation between lesion size and uptake.

PURPOSE

To determine the agreement between the PSMA-RADS and E-PSMA standardized reporting systems in the classification of [F]PSMA-1007-uptaking lesions identified on PET/CT scan in patients with prostate cancer (PCa) and post-prostatectomy with suspected recurrent disease (local recurrence, regional nodal involvement and distant metastases), based on biochemical recurrence, while also exploring the correlation between lesion size and tracer uptake.

MATERIALS AND METHODS

A retrospective cross-sectional study of 32 post-prostatectomy PCa patients who had suspected recurrent disease based on biochemical recurrence post-prostatectomy (prostate-specific antigen values that are 0.2 ng/mL or higher) underwent [F]PSMA-1007 PET/CT scan. The recurrent disease PCa lesions were characterized and subsequently classified using two standardized reporting systems (PSMA-RADS and E-PSMA). The lesions were grouped based on anatomical site, their size and SUVmax were compared using Kruskal-Wallis test with Dunn-Bonferroni tests. Spearman correlation coefficients were calculated between the size of the lesions and their SUVmax of the radiotracer [F]PSMA-1007 for all the lesions and when grouped by anatomical site. Additionally, the agreement between lesion classifications was assessed using Cohen's kappa index.

RESULTS

Only 32 (69.98 ± 8.27, men) patients met the inclusion criteria, a total of 149 lesions with avid uptake of [F]PSMA-1007 were identified. Positive correlation ( = 0.516,  < 0.001) was observed between the size of the metastatic prostate cancer lymph node lesions and their [F]PSMA-1007 uptake. Substantial agreement was noted between the PSMA-RADS and E-PSMA classification system scores among all lesions (κ = 0.70,  < 0.001), with notable discrepancies primarily among lymph node lesions.

CONCLUSION

Our findings revealed a positive correlation between the size of the metastatic prostate cancer lymph node lesions and [F]PSMA-1007 uptake, and although there was substantial agreement between the PSMA-RADS and E-PSMA classification systems, there were discrepancies mainly among the lymph node lesions.