Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland, Australia.
Eur J Neurosci. 2024 Jul;60(2):3823-3827. doi: 10.1111/ejn.16335. Epub 2024 Mar 28.
Since the discovery of the genetic origin of the circadian clock in Drosophila melanogaster by Konopka and Benzer in 1971, most of the research about the regulation of the molecular circadian clock relies on laboratory models. Additional models such as Cyanobacteria, Neurospora crassa, Arabidopsis and rodents helped chronobiologists to describe the species-specific molecular clocks and their regulation. However, the lack of tools and the difficulty to access biological samples somehow excluded human from this research landscape outside behavioural research. Among many other impressive achievements, Steve Brown provided to the community of chronobiologists new tools and strategies to study the individual human circadian clock and its regulation.
自 1971 年 Konopka 和 Benzer 在果蝇中发现生物钟的遗传起源以来，大多数关于分子生物钟调控的研究都依赖于实验室模型。蓝藻、粗糙脉孢菌、拟南芥和啮齿动物等其他模型帮助生物钟学家描述了物种特异性的分子钟及其调控。然而，由于缺乏工具和难以获取生物样本，人类在行为研究之外的这个研究领域中被排除在外。在 Steve Brown 取得的众多令人印象深刻的成就中，他为生物钟学家社区提供了新的工具和策略，以研究个体的人类生物钟及其调控。
