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罕见的喉咙痛:一例甲状腺风暴和粒细胞缺乏症病例

The Rare Sore Throat: A Case of Thyroid Storm and Agranulocytosis.

作者信息

Kunz Matthew J, Martini Wayne A, Filler Levi

机构信息

Creighton of Phoenix Arizona (COPA), Emergency Medicine, Phoenix, Arizona.

Mayo Clinic, Department of Emergency Medicine, Phoenix, Arizona.

出版信息

Clin Pract Cases Emerg Med. 2024 Feb;8(1):34-37. doi: 10.5811/cpcem.6609.

DOI:10.5811/cpcem.6609
PMID:38546308
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10966501/
Abstract

INTRODUCTION

Thyroid storm is a rare but potentially life-threatening metabolic disorder that presents unique management challenges in the emergency department. Thionamides are commonly used as monotherapy for first-line treatment of hyperthyroidism.

CASE REPORT

In this case, a 26-year-old male presented to the emergency department with sore throat, fever, and diarrhea. He was found to have thyrotoxicosis as well as methimazole-induced bone marrow suppression resulting in agranulocytosis.

CONCLUSION

Thyroid storm is a rare condition that carries a high risk of mortality and can further compromise a patient's immune system due to complications of common treatment modalities. It can potentially be misdiagnosed as sepsis due to tachycardia, febrile state, and tachypnea. This case report includes a discussion of diagnostic studies, as well as medical and surgical treatment modalities that led to the patient's recovery.

摘要

引言

甲状腺风暴是一种罕见但可能危及生命的代谢紊乱疾病,在急诊科面临独特的管理挑战。硫代酰胺类药物通常作为单一疗法用于甲亢的一线治疗。

病例报告

在本病例中,一名26岁男性因咽痛、发热和腹泻就诊于急诊科。他被发现患有甲状腺毒症以及甲巯咪唑引起的骨髓抑制导致粒细胞缺乏症。

结论

甲状腺风暴是一种罕见疾病,具有高死亡率风险,并且由于常见治疗方式的并发症可能进一步损害患者的免疫系统。由于心动过速、发热状态和呼吸急促,它可能被误诊为脓毒症。本病例报告包括对诊断研究以及导致患者康复的内科和外科治疗方式的讨论。

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本文引用的文献

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Effect of Ultrashort-Acting β-Blockers on Mortality in Patients With Sepsis With Persistent Tachycardia Despite Initial Resuscitation: A Systematic Review and Meta-analysis of Randomized Controlled Trials.超短效β受体阻滞剂对初始复苏后持续性心动过速的脓毒症患者死亡率的影响:一项随机对照试验的系统评价和荟萃分析。
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Patterns of Use, Efficacy, and Safety of Treatment Options for Patients with Graves' Disease: A Nationwide Population-Based Study.Graves 病患者治疗选择的使用模式、疗效和安全性:一项全国范围内基于人群的研究。
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Clinical characteristics and outcome of thyroid storm: a case series and review of neuropsychiatric derangements in thyrotoxicosis.甲状腺危象的临床特征与转归:病例系列及甲状腺毒症神经精神紊乱综述
Endocr Pract. 2015 Feb;21(2):182-9. doi: 10.4158/EP14023.OR.
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Clinical features and hospital outcomes in thyroid storm: a retrospective cohort study.甲状腺危象的临床特征与住院结局:一项回顾性队列研究
J Clin Endocrinol Metab. 2015 Feb;100(2):451-9. doi: 10.1210/jc.2014-2850. Epub 2014 Oct 24.
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Management of sepsis in neutropenic patients: 2014 updated guidelines from the Infectious Diseases Working Party of the German Society of Hematology and Medical Oncology (AGIHO).中性粒细胞减少患者脓毒症的管理:德国血液学和医学肿瘤学会传染病工作组(AGIHO)2014年更新指南
Ann Hematol. 2014 Jul;93(7):1083-95. doi: 10.1007/s00277-014-2086-0. Epub 2014 Apr 29.
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Sepsis mimicking thyroid storm in a patient with methimazole-induced agranulocytosis.在一名患有甲巯咪唑诱导的粒细胞缺乏症的患者中,脓毒症酷似甲状腺危象。
BMJ Case Rep. 2013 Jul 16;2013:bcr2013200145. doi: 10.1136/bcr-2013-200145.
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Thyroid emergencies.甲状腺危象。
Med Clin North Am. 2012 Mar;96(2):385-403. doi: 10.1016/j.mcna.2012.01.015. Epub 2012 Feb 17.
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Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the infectious diseases society of america.抗菌药物在肿瘤中性粒细胞减少患者应用的临床实践指南:美国传染病学会 2010 年更新版。
Clin Infect Dis. 2011 Feb 15;52(4):e56-93. doi: 10.1093/cid/cir073.
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Population-based drug-induced agranulocytosis.基于人群的药物性粒细胞缺乏症。
Arch Intern Med. 2005 Apr 25;165(8):869-74. doi: 10.1001/archinte.165.8.869.