Department of Biomedical Engineering, Sahand University of Technology, Tabriz, Iran.
Sci Rep. 2024 Mar 28;14(1):7443. doi: 10.1038/s41598-024-57019-9.
With improved treatment of coronary artery disease, more patients are surviving until heart failure occurs. This leads to an increase in patients needing devices for struggling with heart failure. Ventricular assist devices are known as the mainstay of these devices. This study aimed to design a centrifugal pump as a ventricular assist device. In order to design the pump, firstly, the geometrical parameters of the pump, including the gap distance, blade height, and position of the outlet relative to the blade, were investigated. Finally, the selected configuration, which had all the appropriate characteristics, both hydraulically and physiologically, was used for the rest of the study. The study of the blade, as the main component in energy transfer to the blood, in a centrifugal pump, has been considered in the present study. In this regard, the point-to-point design method, which is used in industrial applications, was implemented. The designer chooses the relationship between the blade angles at each radius in the point-to-point method. The present study selected logarithmic and second-order relations for designing the blade's profile. In total, 58 blades were examined in this study, which differed regarding blade inlet and outlet angles and the relationship between angle and radial position. ANSYS CFX 17.0 software was utilized to simulate blades' performances, and a benchmark pump provided by the US Food and Drug Administration (FDA) was used to validate the numerical simulations. Then, the selected impeller from the numerical investigation was manufactured, and its performance was compared experimentally with the FDA benchmark pump. A hydraulic test rig was also developed for experimental studies. The results showed that among the blades designed in this study, the blade with an input angle of 45° and an output angle of 55°, which is designed to implement a logarithmic relationship, has the best performance. The selected impeller configuration can increase the total head (at least by 20%) at different flow rates compared to the FDA pump.
随着冠状动脉疾病治疗水平的提高，越来越多的患者能够存活到心力衰竭发生。这导致需要设备来治疗心力衰竭的患者数量增加。心室辅助装置是这些设备的主要支柱。本研究旨在设计一种离心式泵作为心室辅助装置。为了设计该泵，首先研究了泵的几何参数，包括间隙距离、叶片高度和叶片出口相对于叶片的位置。最后，选择了具有所有适当特征的配置，无论是在液压还是生理方面，都将用于其余的研究。在本研究中，研究了叶片作为向血液传递能量的主要部件在离心式泵中的作用。在这方面，实施了点到点设计方法，该方法用于工业应用。设计师在点到点方法中选择每个半径处叶片角度之间的关系。本研究选择对数和二阶关系来设计叶片轮廓。总共在本研究中检查了 58 个叶片，它们在叶片进出口角度和角度与径向位置之间的关系方面有所不同。利用 ANSYS CFX 17.0 软件模拟叶片性能，并使用美国食品和药物管理局（FDA）提供的基准泵验证数值模拟。然后，从数值研究中选择的叶轮进行制造，并将其性能与 FDA 基准泵进行了实验比较。还开发了一个液压试验台进行实验研究。结果表明，在本研究设计的叶片中，输入角度为 45°、输出角度为 55°、设计实施对数关系的叶片具有最佳性能。与 FDA 泵相比，选择的叶轮配置可以在不同流量下增加总扬程（至少增加 20%）。
