Department of Geriatric, HuZhou Third Municipal Hospital, the Affiliated Hospital of Huzhou University, 2088 Tiaoxi East Road, Wuxing District, Huzhou City, Zhejiang Province, China.
BMC Pulm Med. 2024 Mar 28;24(1):157. doi: 10.1186/s12890-024-02971-5.
Extracorporeal membrane oxygenation (ECMO) is used when standard methods of standard treatment methods are not successful. Obese patients present unique challenges during ECMO due to large body size hindering sufficient flows, difficulties with patient positioning and anatomical landmark identification, and restricted radiology scans. This meta-analysis aims to investigate the impact of obesity on the outcomes of patients undergoing ECMO.
Databases (PubMed, Embase, and Scopus databases) were searched to identify relevant studies published until July 2023. Data were reported as odds ratios (OR) with 95% confidence interval (CI), and the descriptive data were reported as standard difference of means (SDM) by a random effects model.
A literature search identified 345 studies. Of them, 18 studies met the inclusion criteria. The findings from the meta-analysis revealed no significant association between obesity and survival outcomes after ECMO (odds ratio (OR): 0.91, 95% confidence interval (CI): 0.70-1.17, p: 0.46). Moreover, no comparative significant differences were found between obese and non-obese individuals on the duration of ECMO procedure (standardized mean difference (SMD): 0.07, -0.03-0.17), length of hospital stay (-0.03, -0.19 to 0.12), and duration of ventilation support (-0.10, -0.44 to 0.24).
The meta-analysis findings suggest no significant impact of obesity on the survival outcomes after the ECMO procedure. There was no significant impact of obesity on the duration of ECMO procedures, length of hospital stay, and duration of ventilation support.
体外膜肺氧合（ECMO）在标准治疗方法不成功时使用。肥胖患者在 ECMO 期间会出现独特的挑战，因为大身体尺寸会阻碍足够的流量，患者定位和解剖标志识别困难，以及限制放射学扫描。这项荟萃分析旨在研究肥胖对接受 ECMO 治疗的患者结局的影响。
搜索数据库（PubMed、Embase 和 Scopus 数据库）以确定截至 2023 年 7 月发表的相关研究。数据以优势比（OR）和 95%置信区间（CI）报告，描述性数据以随机效应模型报告为均值的标准差值（SDM）。
文献检索确定了 345 项研究。其中，18 项研究符合纳入标准。荟萃分析的结果表明，肥胖与 ECMO 后生存结局之间没有显著关联（OR：0.91，95%CI：0.70-1.17，p：0.46）。此外，肥胖和非肥胖个体在 ECMO 程序持续时间（标准化均数差（SMD）：0.07，-0.03-0.17）、住院时间（-0.03，-0.19 至 0.12）和通气支持持续时间（-0.10，-0.44 至 0.24）方面没有发现统计学上的显著差异。
荟萃分析结果表明，肥胖对 ECMO 后生存结局没有显著影响。肥胖对 ECMO 程序持续时间、住院时间和通气支持持续时间没有显著影响。
