Wu Yi, Zhang Feng, Kuang Dan, Li Dan, Yan Jiai, Yang Ju, Wang Qinyue, Wang Yingyu, Sun Jing, Liu Yiran, Xia Yanping, Cao Hong
Nutritional Department, Affiliated Hospital of Jiangnan University, Wuxi, China.
Wuxi School of Medicine, Jiangnan University, Wuxi, China.
Front Pharmacol. 2024 Mar 14;15:1162883. doi: 10.3389/fphar.2024.1162883. eCollection 2024.
In clinical practice, antibiotics and/or inhaled or oral hormone preparations are the first line of treatment for chronic pharyngitis. However, this therapeutic regimen is not satisfactory enough. At present, medicinal plants as dietary supplements or functional foods are widely recognized for the treatment and prevention of different diseases. This study aimed to evaluate the efficacy of the botanical lozenge made from several medicinal plant extracts in the treatment of chronic pharyngitis and its effects on patients' illness perception and adherence to treatment. Patients with chronic pharyngitis were randomly assigned to the experimental group (n = 52) or the control group (n = 51). Patients were given botanical lozenges prepared from the extracts of medicinal plants such as (Swingle) C. Jeffrey ex A.M.Lu and Zhi Y. Zhang [Cucurbitaceae; Siraitiae fructus], Thunb [Caprifoliaceae; Lonicerae japonicae flos], (Jacq.) A. DC [Campanulaceae; Platycodon radix], and Fisch. ex DC [Fabaceae; Glycyrrhizae radix et rhizoma] or placebos made of starch for 15 days. The improvement of pharyngeal symptoms and signs, illness perception, and adherence to treatment were evaluated at the end of the intervention. The total score of pharyngeal symptoms of patients in the experimental group (3.33 ± 2.33) was significantly lower than that in the control group (5.20 ± 2.93) ( < 0.01). In comparison to the control group (3.43 ± 1.43), the total pharyngeal signs score of patients in the experimental group (2.69 ± 1.59) was considerably lower ( 0.01). The improvement rates of pharyngeal itching, dry throat, pharyngeal foreign body sensation, aggravation due to excessive speaking, and congestion of pharyngeal mucosa in the experimental group were 73.81%, 67.50%, 67.57%, 65.22% and 44%, respectively, which were significantly higher than those in the control group ( 0.05). In addition, patients taking botanical lozenges had better illness perception and adherence to treatment than those taking placebos ( < 0.05). Patients with low adherence to treatment showed less personal control, concerns, and understanding of chronic pharyngitis ( < 0.05). Botanical lozenges not only aided patients in recovering from chronic pharyngitis but also improved their positive perceptions of the disease, which helped them adhere to their treatment regimen. : [https://www.chictr.org.cn/], identifier [ChiCTR2200062139].
在临床实践中，抗生素和/或吸入或口服激素制剂是慢性咽炎的一线治疗方法。然而，这种治疗方案并不够令人满意。目前，药用植物作为膳食补充剂或功能性食品在治疗和预防不同疾病方面得到了广泛认可。本研究旨在评估由几种药用植物提取物制成的植物含片对慢性咽炎的治疗效果及其对患者疾病认知和治疗依从性的影响。慢性咽炎患者被随机分为实验组（n = 52）或对照组（n = 51）。给予患者由罗汉果（葫芦科；罗汉果）、金银花（忍冬科；忍冬花）、桔梗（桔梗科；桔梗根）、甘草（豆科；甘草根及根茎）等药用植物提取物制备的植物含片或由淀粉制成的安慰剂，持续15天。在干预结束时评估咽部症状和体征的改善情况、疾病认知和治疗依从性。实验组患者的咽部症状总评分（3.33±2.33）显著低于对照组（5.20±2.93）（P<0.01）。与对照组（3.43±1.43）相比，实验组患者的咽部体征总评分（2.69±1.59）明显更低（P<0.01）。实验组咽部瘙痒、咽干、咽部异物感、多言加重及咽黏膜充血的改善率分别为73.81%、67.50%、67.57%、65.22%和44%，均显著高于对照组（P<0.05）。此外，服用植物含片的患者比服用安慰剂的患者对疾病的认知更好，治疗依从性更高（P<0.05）。治疗依从性低的患者对慢性咽炎的个人控制感、关注度和理解度较低（P<0.05）。植物含片不仅有助于患者从慢性咽炎中康复，还改善了他们对疾病的积极认知，这有助于他们坚持治疗方案。：[https://www.chictr.org.cn/]，标识符[ChiCTR2200062139]
