Post-Graduation Programme in Medical Sciences, School of Medical Sciences, State University of Rio de Janeiro (UERJ), Rio de Janeiro, Brazil.
Department of Pulmonology, Piquet Carneiro Polyclinic, State University of Rio de Janeiro (UERJ), Rio de Janeiro, Brazil.
Physiother Res Int. 2024 Apr;29(2):e2087. doi: 10.1002/pri.2087.
Cardiopulmonary and skeletal muscle impairment and poor physical activity are potential contributors to reduced functional capacity in cystic fibrosis (CF). The Glittre-ADL test (TGlittre) has great potential for clinical use in adult CF adults, as it meets the need for a comprehensive assessment of physical function using tasks similar to activities of daily living. This study aimed to evaluate the performance of TGlittre in CF adults compared to the 6-min walk test (6MWT) and, secondarily, to quantify the associations of their results with pulmonary function, muscle strength, and health-related quality of life (HRQoL).
This cross-sectional study evaluated 34 CF adults and compared them with 34 subjects from a control group. The participants underwent the following assessments: functional capacity using TGlittre and 6MWT; spirometry; respiratory muscle strength; handgrip strength (HGS); and HRQoL using the Cystic Fibrosis Questionnaire-Revised (CFQ-R).
While CF patients showed a longer time to perform TGlittre compared to controls (134 (119-150) versus 107 (95-126) % of the predicted time p = 0.0002), no difference between these groups was observed in the 6MWT. When the second TGlittre was compared to the first TGlittre, there was a significant decrease in total time for both CF patients (p < 0.0001) and controls (p = 0.0001). TGlittre time correlated with 6MWT distance (6MWD) (r = -0.641, p < 0.0001), HGS (r = -0.364, p = 0.034), peripheral oxygen saturation at the end of the test (r = -0.463, p = 0.006) and the "digestive symptoms" domain of CFQ-R (r = 0.376, p = 0.028). TGlittre time was shorter in patients who engaged in regular physical activity (3.10 (2.49-3.39) min versus 3.28 (2.95-3.53) min, p = 0.016).
TGlittre is more effective than the 6MWT in detecting limitations during exercise. There is an important learning effect of TGlittre in adult CF patients. TGlittre time was correlated with 6MWD, HGS, oxygen saturation level, and the patient's level of physical activity.
心肺和骨骼肌损伤以及体力活动不足可能是囊性纤维化（CF）患者功能能力下降的潜在原因。Glittre-ADL 测试（TGlittre）在 CF 成年患者中有很大的临床应用潜力，因为它满足了使用类似于日常生活活动的任务对身体功能进行全面评估的需求。本研究旨在评估 TGlittre 在 CF 成年患者中的表现，并与 6 分钟步行测试（6MWT）进行比较，其次，量化其结果与肺功能、肌肉力量和健康相关生活质量（HRQoL）的相关性。
这是一项横断面研究，共评估了 34 名 CF 成年患者，并将其与 34 名对照组患者进行了比较。参与者接受了以下评估：使用 TGlittre 和 6MWT 进行功能能力评估；肺功能测定；呼吸肌力量；手握力（HGS）；使用囊性纤维化问卷修订版（CFQ-R）进行健康相关生活质量（HRQoL）评估。
虽然 CF 患者完成 TGlittre 的时间比对照组患者长（134（119-150）%与 107（95-126）%的预计时间相比，p=0.0002），但两组在 6MWT 上无差异。当比较第二次 TGlittre 与第一次 TGlittre 时，CF 患者（p<0.0001）和对照组（p=0.0001）的总时间均显著下降。TGlittre 时间与 6MWT 距离（6MWD）（r=-0.641，p<0.0001）、HGS（r=-0.364，p=0.034）、测试结束时外周血氧饱和度（r=-0.463，p=0.006）和 CFQ-R 的“消化症状”域（r=0.376，p=0.028）相关。经常进行体育锻炼的患者完成 TGlittre 的时间更短（3.10（2.49-3.39）分钟与 3.28（2.95-3.53）分钟，p=0.016）。
与 6MWT 相比，TGlittre 更能有效地检测运动期间的运动限制。CF 成年患者的 TGlittre 有重要的学习效果。TGlittre 时间与 6MWD、HGS、血氧饱和度水平和患者的体力活动水平相关。
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