文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

行为和人类剪接（DBHS）家族的 RNA 结合蛋白在健康和癌症中的作用。

Role of RNA binding proteins of the behavior and human splicing (DBHS) family in health and cancer.

机构信息

Department of Systems Aging Science and Medicine, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Itabashi-ku, Tokyo, Japan.

Division of Systems Medicine & Gene Therapy, Faculty of Medicine, Saitama Medical University, Hidaka, Saitama, Japan.

出版信息

RNA Biol. 2024 Jan;21(1):1-17. doi: 10.1080/15476286.2024.2332855. Epub 2024 Mar 29.

DOI:10.1080/15476286.2024.2332855
PMID:38551131
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10984136/
Abstract

RNA-binding proteins (RBPs) play crucial roles in the functions and homoeostasis of various tissues by regulating multiple events of RNA processing including RNA splicing, intracellular RNA transport, and mRNA translation. The behavior and human splicing (DBHS) family proteins including PSF/SFPQ, NONO, and PSPC1 are ubiquitously expressed RBPs that contribute to the physiology of several tissues. In mammals, DBHS proteins have been reported to contribute to neurological diseases and play crucial roles in cancers, such as prostate, breast, and liver cancers, by regulating cancer-specific gene expression. Notably, in recent years, multiple small molecules targeting DBHS family proteins have been developed for application as cancer therapeutics. This review provides a recent overview of the functions of DBHS family in physiology and pathophysiology, and discusses the application of DBHS family proteins as promising diagnostic and therapeutic targets for cancers.

摘要

RNA 结合蛋白（RBPs）通过调节 RNA 剪接、细胞内 RNA 运输和 mRNA 翻译等多种 RNA 处理事件，在各种组织的功能和动态平衡中发挥着关键作用。PSF/SFPQ、NONO 和 PSPC1 等 DBHS（行为和人类剪接）家族蛋白是广泛表达的 RBPs，它们有助于几种组织的生理机能。在哺乳动物中，DBHS 蛋白已被报道有助于神经疾病，并通过调节特定于癌症的基因表达在癌症中发挥关键作用，例如前列腺癌、乳腺癌和肝癌。值得注意的是，近年来，已经开发出多种针对 DBHS 家族蛋白的小分子药物，可作为癌症治疗药物。本综述提供了 DBHS 家族在生理和病理生理学中的最新功能概述，并讨论了将 DBHS 家族蛋白作为癌症有前途的诊断和治疗靶点的应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83b4/10984136/66383eae4006/KRNB_A_2332855_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83b4/10984136/405984438971/KRNB_A_2332855_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83b4/10984136/305834fe5e5d/KRNB_A_2332855_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83b4/10984136/66383eae4006/KRNB_A_2332855_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83b4/10984136/405984438971/KRNB_A_2332855_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83b4/10984136/305834fe5e5d/KRNB_A_2332855_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83b4/10984136/66383eae4006/KRNB_A_2332855_F0003_OC.jpg

相似文献

[1]
Role of RNA binding proteins of the behavior and human splicing (DBHS) family in health and cancer.

RNA Biol. 2024-1

[2]
Crystal structure of a SFPQ/PSPC1 heterodimer provides insights into preferential heterodimerization of human DBHS family proteins.

J Biol Chem. 2018-3-12

[3]
Paraspeckle subnuclear bodies depend on dynamic heterodimerisation of DBHS RNA-binding proteins via their structured domains.

J Biol Chem. 2022-11

[4]
Structural plasticity of the coiled-coil interactions in human SFPQ.

Nucleic Acids Res. 2025-1-11

[5]
The DBHS proteins SFPQ, NONO and PSPC1: a multipurpose molecular scaffold.

Nucleic Acids Res. 2016-5-19

[6]
Structural basis of dimerization and nucleic acid binding of human DBHS proteins NONO and PSPC1.

Nucleic Acids Res. 2022-1-11

[7]
Structure of the heterodimer of human NONO and paraspeckle protein component 1 and analysis of its role in subnuclear body formation.

Proc Natl Acad Sci U S A. 2012-3-13

[8]
Molecular Modelling of NONO and SFPQ Dimerization Process and RNA Recognition Mechanism.

Int J Mol Sci. 2022-7-10

[9]
Crystal structure of SFPQ-NONO heterodimer.

Biochimie. 2022-7

[10]
Dynamic paraspeckle component localisation during spermatogenesis.

Reproduction. 2019-9

引用本文的文献

[1]
Alternative Splicing in Tumorigenesis and Cancer Therapy.

Biomolecules. 2025-5-29

[2]
The implication of non-AUG-initiated N-terminally extended proteoforms in cancer.

RNA Biol. 2025-12

[3]
Structural plasticity of the coiled-coil interactions in human SFPQ.

Nucleic Acids Res. 2025-1-11

[4]
An N-terminal and ankyrin repeat domain interactome of Shank3 identifies the protein complex with the splicing regulator Nono in mice.

Genes Cells. 2024-9

[5]
Synergistic Immunoregulation: harnessing CircRNAs and PiRNAs to Amplify PD-1/PD-L1 Inhibition Therapy.

Int J Nanomedicine. 2024

本文引用的文献

[1]
Different Low-complexity Regions of SFPQ Play Distinct Roles in the Formation of Biomolecular Condensates.

J Mol Biol. 2023-12-15

[2]
Shell protein composition specified by the lncRNA NEAT1 domains dictates the formation of paraspeckles as distinct membraneless organelles.

Nat Cell Biol. 2023-11

[3]
LncRNA like NMRK2 mRNA functions as a key molecular scaffold to enhance mitochondrial respiration of NONO-TFE3 rearranged renal cell carcinoma in an NAD kinase-independent manner.

J Exp Clin Cancer Res. 2023-9-28

[4]
Novel NONO::TFE3 fusion and ALK co-expression identified in a subset of cutaneous microcystic/reticular schwannoma.

Virchows Arch. 2023-8

[5]
Identification of small-molecule inhibitors against the interaction of RNA-binding protein PSF and its target RNA for cancer treatment.

PNAS Nexus. 2023-6-21

[6]
K235 acetylation couples with PSPC1 to regulate the mA demethylation activity of ALKBH5 and tumorigenesis.

Nat Commun. 2023-6-27

[7]
Stress granules sequester Alzheimer's disease-associated gene transcripts and regulate disease-related neuronal proteostasis.

Aging (Albany NY). 2023-5-22

[8]
Remodeling oncogenic transcriptomes by small molecules targeting NONO.

Nat Chem Biol. 2023-7

[9]
NONO enhances mRNA processing of super-enhancer-associated GATA2 and HAND2 genes in neuroblastoma.

EMBO Rep. 2023-2-6

[10]
Targeting phase separation on enhancers induced by transcription factor complex formations as a new strategy for treating drug-resistant cancers.

Front Oncol. 2022-10-3

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索