益生菌补充剂治疗银屑病的疗效：系统评价和荟萃分析。

Efficacy of probiotic supplementation in the treatment of psoriasis-A systematic review and meta-analysis.

机构信息

Clinical Research on Skin Diseases, School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Department of Dermatology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.

出版信息

J Cosmet Dermatol. 2024 Jul;23(7):2361-2367. doi: 10.1111/jocd.16299. Epub 2024 Mar 29.

DOI:10.1111/jocd.16299

PMID:38551321

Abstract

OBJECTIVE

Many studies have emphasized the possible role of probiotics in psoriasis, probiotic supplementation might be helpful to treat psoriasis. This study systematically evaluated the efficacy of probiotic supplementation for the treatment of psoriasis.

METHODS

We searched some databases with keywords until November 10, 2023, including PubMed, Cochrane Library, Embase, and Web of Science. These keywords included probiotics, psoriasis RCT, and so on. After rigorous literature screening by two authors, five studies were identified. Eventually, the required data were independently extracted by another author.

RESULTS

A total of five studies with 286 patients were included. The pooled results showed that the efficacy of probiotic supplementation was superior to placebo in the treatment of psoriasis. The Psoriasis Area and Severity Index (SMD = -1.40, 95% Cl = -2.63 to -0.17, p < 0.00001) and Dermatology Life Quality Index (SMD = -0.92, 95% Cl = -1.86 to 0.01, p < 0.00001). Score decreased after probiotic supplementation.

CONCLUSIONS

The meta-analysis showed that probiotic supplementation could be a new treatment option for psoriasis.

摘要

目的

许多研究强调了益生菌在银屑病中的可能作用，益生菌补充剂可能有助于治疗银屑病。本研究系统评估了益生菌补充剂治疗银屑病的疗效。

方法

我们使用关键词在一些数据库中进行搜索，检索时间截至 2023 年 11 月 10 日，包括 PubMed、Cochrane Library、Embase 和 Web of Science。这些关键词包括益生菌、银屑病 RCT 等。两位作者经过严格的文献筛选，确定了五项研究。最后，另一位作者独立提取了所需的数据。

结果

共纳入五项研究，共计 286 例患者。汇总结果显示，益生菌补充剂在治疗银屑病方面的疗效优于安慰剂。银屑病面积和严重程度指数（SMD =-1.40，95%Cl=-2.63 至-0.17，p<0.00001）和皮肤病生活质量指数（SMD=-0.92，95%Cl=-1.86 至 0.01，p<0.00001）评分均降低。