在酒精成瘾中胰岛淀粉样多肽：一种新的潜在治疗靶点或其他治疗方法的辅助手段？
Amylin in Alcohol Addiction: A Potential New Treatment Target or an Adjuvant to Other Treatments?
机构信息
Clinical Psychoneuroendocrinology and Neuropsychopharmacology Section, Translational Addiction Medicine Branch, National Institute on Drug Abuse Intramural Research Program and National Institute on Alcohol Abuse and Alcoholism Division of Intramural Clinical and Biological Research, National Institutes of Health, Baltimore, Maryland 21224, United States.
Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, United States.
出版信息
ACS Chem Neurosci. 2024 Apr 17;15(8):1609-1610. doi: 10.1021/acschemneuro.4c00133. Epub 2024 Mar 29.
Amylin is a neuroendocrine hormone with a potential role in addictive disorders, including alcohol use disorder (AUD). In addition to reducing appetitive behavior, amylin has been shown to affect alcohol-related behaviors in rodents. Delineating the biobehavioral correlates of amylin in relation to alcohol seeking and consumption has the potential of identifying new treatment targets for AUD, yet additional translational and human research is needed.
胰淀素是一种神经内分泌激素，它在成瘾障碍中具有潜在作用，包括酒精使用障碍（AUD）。除了减少食欲行为外，胰淀素还被证明会影响啮齿动物的酒精相关行为。阐明胰淀素与酒精寻求和消费相关的生物行为相关性，有可能为 AUD 确定新的治疗靶点，但需要更多的转化和人类研究。
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