Tanaka Y
Int J Lepr Other Mycobact Dis. 1979 Sep;47(3):486-94.
C3H mice stimulated with M. lepraemurium cell wall skeletons (LM-CWS) were challenged with viable M. lepraemurium, and delayed-type hypersensitivity (DTH) to picryl chloride was measured. In one type of experiment the mice were challenged at the time when stimulation of cell-mediated resistance by means of LM-CWS was undertaken. The major purpose was to investigate principles pertaining to immunotherapy. In contrast to the loss of a detectable DTH response to picryl chloride, development of murine leprosy was partially suppressed. In the second type of experiment the mice were stimulated with oil-attached LM-CWS seven weeks before challenge with M. lepraemurium. Findings were: a) that nonspecific DTH as measured by sensitization and challenge with picryl chloride was activated before the infection with M. lepraemurium and b) that the DTH which developed was associated with partial protection against the growth of lepromata. The murine leprosy which developed in C3H mice stimulated with LM-CWS was progressive after some delay.
用鼠麻风杆菌细胞壁骨架（LM - CWS）刺激C3H小鼠后，再用活的鼠麻风杆菌攻击，然后检测对苦味酸氯的迟发型超敏反应（DTH）。在一种实验类型中，小鼠在通过LM - CWS刺激细胞介导的抗性时受到攻击。主要目的是研究免疫治疗的相关原理。与对苦味酸氯的可检测DTH反应丧失相反，鼠麻风的发展得到了部分抑制。在第二种实验类型中，小鼠在被鼠麻风杆菌攻击前7周用附着油的LM - CWS刺激。结果是：a）在用苦味酸氯致敏和攻击所测量的非特异性DTH在感染鼠麻风杆菌之前就被激活，以及b）所产生的DTH与对麻风瘤生长的部分保护相关。用LM - CWS刺激的C3H小鼠中发展出的鼠麻风在经过一段时间延迟后呈进行性发展。
