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内镜下十二指肠黏膜消融术:糖尿病治疗的未来?

Endoscopic duodenal mucosa ablation: the future of diabetes treatment?

机构信息

MECAU, San Luigi Gonzaga Hospital, University of Turin, Turin, Italy.

Department of Medical Sciences, Città della Salute e della Scienza, University of Turin, Turin, Italy.

出版信息

Trends Mol Med. 2024 Jul;30(7):612-616. doi: 10.1016/j.molmed.2024.03.003. Epub 2024 Mar 29.

Abstract

Duodenal mucosa ablation (DMA) is a novel approach to treat diabetes, consisting of endoscopic ablation of dysfunctional diabetic duodenal mucosa, which, following the healing response, is replaced by normally functioning mucosa. Two techniques, duodenal mucosal resurfacing (DMR) and recellularization via electroporation therapy (ReCET), recently showed promise in type 2 diabetes mellitus (T2DM) patients.

摘要

十二指肠黏膜消融术(DMA)是一种治疗糖尿病的新方法,包括对功能失调的糖尿病性十二指肠黏膜进行内镜消融,随后在愈合反应后,正常功能的黏膜会取代病变黏膜。最近,两种技术,即十二指肠黏膜表面重塑(DMR)和电穿孔治疗的再细胞化(ReCET),在 2 型糖尿病(T2DM)患者中显示出了前景。

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