Avnstrøm S, Ralfkiar E, Winkel P, Nissen N I
Am J Clin Pathol. 1985 Jan;83(1):73-6. doi: 10.1093/ajcp/83.1.73.
Eighteen patients with acute myeloblastic leukemia were monitored using an automated differential analyzer (Hemalog D). Twelve patients achieved complete remission. The fraction of large unstained cells (LUC), lymphocytes (LYMPH), the ratio LUC/LYMPH, WBC, and LUC X WBC as measured on day 12 following start of induction chemotherapy differed significantly between patients who did not respond and patients who did achieve remission. The quantity LUC/LYMPH was by far the best discriminator. In patients who achieved remission, the median value was 0.047 and the range was 0.017-0.088. In patients who did not, the corresponding values were 0.163 and 0.12-0.32. Hemalog D examination of peripheral blood on day 12 after initiation of treatment thus seems to give an early prediction of remission as defined by morphologic examination of bone marrow.
使用自动血液分析仪（Hemalog D）对18例急性髓细胞白血病患者进行监测。12例患者实现完全缓解。诱导化疗开始后第12天测得的大未染色细胞（LUC）、淋巴细胞（LYMPH）、LUC/LYMPH比值、白细胞（WBC）以及LUC×WBC在未缓解患者和实现缓解的患者之间存在显著差异。LUC/LYMPH数值是迄今为止最佳的判别指标。实现缓解的患者中，中位数为0.047，范围为0.017 - 0.088。未实现缓解的患者中，相应数值为0.163，范围为0.12 - 0.32。因此，治疗开始后第12天对外周血进行Hemalog D检测似乎能对骨髓形态学检查所定义的缓解情况做出早期预测。
