The Hengyang Key Laboratory of Cellular Stress Biology, Institute of Cytology and Genetics, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
Mol Biol Rep. 2024 Mar 29;51(1):476. doi: 10.1007/s11033-024-09405-9.
Glycosylation modification of proteins is a common post-translational modification that exists in various organisms and has rich biological functions. It is usually catalyzed by multiple glycosyltransferases located in the Golgi apparatus. β-1,3-N-acetylglucosaminyltransferases (B3GNTs) are members of the glycosyltransferases and have been found to be involved in the occurrence and development of a variety of diseases including autoimmunity diseases, cancers, neurodevelopment, musculoskeletal system, and metabolic diseases. The functions of B3GNTs represent the glycosylation of proteins is a crucial and frequently life-threatening step in progression of most diseases. In this review, we give an overview about the roles of B3GNTs in tumor, nervous system, musculoskeletal and metabolic diseases, describing the recent results about B3GNTs, in order to provide a research direction and exploration value for the prevention, diagnosis and treatment of these diseases.
糖基化修饰是一种常见的翻译后修饰，存在于各种生物体中，具有丰富的生物学功能。它通常由位于高尔基体中的多种糖基转移酶催化。β-1,3-N-乙酰氨基葡萄糖转移酶（B3GNTs）是糖基转移酶的成员，已发现其参与多种疾病的发生和发展，包括自身免疫性疾病、癌症、神经发育、肌肉骨骼系统和代谢性疾病。B3GNTs 的功能代表糖基化是大多数疾病进展过程中至关重要且经常危及生命的步骤。在这篇综述中，我们概述了 B3GNTs 在肿瘤、神经系统、肌肉骨骼和代谢性疾病中的作用，描述了关于 B3GNTs 的最新结果，以期为这些疾病的预防、诊断和治疗提供研究方向和探索价值。
