El Sharkawy Sara I, Aboulenien Yousra, Elnagar Basma, Elkhalawany Walaa, Badawi Rehab
Tanta Cardiology Department, Tanta University Faculty of Medicine, Tanta, Egypt.
Tropical Medicine and Infectious Diseases Department, Tanta University Faculty of Medicine, Tanta, Egypt.
Egypt Heart J. 2024 Mar 30;76(1):42. doi: 10.1186/s43044-024-00462-w.
Metabolic-associated fatty liver disease (MAFLD) and cardiovascular diseases have mutual risk factors that contribute to pathogenic processes, increasing mortality and morbidity. This study aimed to evaluate variations in left ventricular (LV) structure and diastolic function among different subtypes and severity degrees of MAFLD patients, allowing early identification, intervention, and prevention of severe cardiac outcomes in high-risk populations.
The cross-sectional study included 142 MAFLD patients and 142 non-MAFLD participants as a control group. All participants underwent abdominal ultrasound, transient elastography, transthoracic echocardiography, tissue Doppler, and strain imaging. The results showed a significant impairment in the diastolic left ventricular function, as assessed with tissue Doppler, and the left atrial (LA) function, as evaluated with strain imaging, in the MAFLD group. Additionally, the left atrial stiffness was significantly higher in the MAFLD group.
The use of strain imaging facilitated the detection of subtle impairments of the left atrial reservoir, contraction, conduit function, and left ventricular diastolic function in MAFLD patients.
代谢相关脂肪性肝病（MAFLD）与心血管疾病具有共同的危险因素，这些因素促成致病过程，增加死亡率和发病率。本研究旨在评估MAFLD患者不同亚型和严重程度之间左心室（LV）结构和舒张功能的变化，以便在高危人群中早期识别、干预和预防严重心脏结局。
横断面研究纳入了142例MAFLD患者和142例非MAFLD参与者作为对照组。所有参与者均接受腹部超声、瞬时弹性成像、经胸超声心动图、组织多普勒和应变成像检查。结果显示，MAFLD组中，用组织多普勒评估的左心室舒张功能以及用应变成像评估的左心房（LA）功能均有显著损害。此外，MAFLD组的左心房僵硬度显著更高。
应变成像的应用有助于检测MAFLD患者左心房储存、收缩、管道功能以及左心室舒张功能的细微损害。
