Department of Child Health and Diseases Nursing, Health Sciences Institute, Bursa Uludağ University, Bursa, Turkey.
Department of First and Emergency Aid, Vocational School of Health Services, Fenerbahçe University, Istanbul, Turkey.
J Perinatol. 2024 May;44(5):717-723. doi: 10.1038/s41372-024-01948-w. Epub 2024 Mar 29.
This study aimed to assess the efficacy of pacifier use, with and without 25% dextrose, in reducing pain during orogastric tube insertion in newborns.
In a randomized controlled trial involving 60 newborns at a public hospital from April to December 2019, participants were divided into three groups: pacifier (n = 20), pacifier with 25% dextrose (n = 20), and control (n = 20). A pacifier, with and without dextrose, was used for the experimental groups, while the control group performed a routine procedure. Neonatal infant pain scale, crying duration, heart rate (HR), and oxygen saturation (SpO2) were evaluated.
Results indicated that the control group experienced significantly higher pain levels, elevated HRs, decreased SpO2, and prolonged crying. Conversely, the pacifier with 25% dextrose group showed a notable reduction in crying duration.
A pacifier, with and without 25% dextrose, effectively reduces pain and improves physiological and behavioral parameters during orogastric tube insertion.
NCT05462964 CLINICAL TRIAL REGISTRATION: The protocol for this randomized controlled experimental trial is registered on ClinicalTrials.gov. The clinical trial registration number is https://clinicaltrials.gov ; NCT05462964.
本研究旨在评估使用安抚奶嘴，联合或不联合 25%葡萄糖，对减轻经口胃管插入新生儿疼痛的效果。
在 2019 年 4 月至 12 月于一家公立医院进行的一项随机对照试验中，纳入了 60 名新生儿，将其分为三组：安抚奶嘴组（n=20）、安抚奶嘴加 25%葡萄糖组（n=20）和对照组（n=20）。实验组使用有或没有葡萄糖的安抚奶嘴，对照组则进行常规操作。评估新生儿疼痛量表、哭泣持续时间、心率（HR）和血氧饱和度（SpO2）。
结果表明，对照组疼痛程度显著更高，HR 升高，SpO2 降低，哭泣时间延长。相比之下，使用 25%葡萄糖的安抚奶嘴组哭泣持续时间显著缩短。
使用或不使用 25%葡萄糖的安抚奶嘴可有效减轻经口胃管插入新生儿的疼痛，并改善生理和行为参数。
NCT05462964
该随机对照实验试验方案已在 ClinicalTrials.gov 上注册。临床试验注册号为 https://clinicaltrials.gov；NCT05462964。
