Department of Pathology, Dr. D.Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth, Pimpri, Pune, Maharashtra, India.
J Cancer Res Ther. 2024 Jan 1;20(1):476-478. doi: 10.4103/jcrt.jcrt_1772_22. Epub 2023 May 2.
Multiple myeloma is a malignant plasma cell condition that mostly affects the skeletal system and bone marrow. Pleural effusions are uncommon and typically result from other conditions coexisting with multiple myeloma. Malignant myelomatous pleural effusions are rare complications of multiple myeloma, occurring in less than 1% of patients and are associated with poor prognosis having mean survival of less than 4 months. The present case report is a 41-year-old multiple myeloma patient who developed bilateral pleural effusion at a disease relapse. Chemotherapeutic regimen of cyclophosphamide, bortezomib, and dexamethasone given. Despite a positive response to treatment, the patient's condition worsened over the course of following month and he eventually passed away. Myelomatous pleural effusion indicates poor prognosis and early consideration helps in quick diagnosis and initiation of treatment which may help in improving prognosis.
多发性骨髓瘤是一种主要影响骨骼系统和骨髓的恶性浆细胞疾病。胸腔积液并不常见，通常是由多发性骨髓瘤合并的其他疾病引起的。恶性浆细胞瘤性胸腔积液是多发性骨髓瘤的罕见并发症，不到 1%的患者发生，预后不良，平均生存时间不到 4 个月。本病例报告是一名 41 岁的多发性骨髓瘤患者，在疾病复发时出现双侧胸腔积液。给予环磷酰胺、硼替佐米和地塞米松的化疗方案。尽管对治疗有积极反应，但在接下来的一个月里，患者的病情恶化，最终去世。浆细胞瘤性胸腔积液提示预后不良，早期考虑有助于快速诊断和开始治疗，从而可能改善预后。
