Department of Pathology, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India.
J Cancer Res Ther. 2024 Jan 1;20(1):482-484. doi: 10.4103/jcrt.jcrt_2085_22. Epub 2023 Apr 5.
Renal cell carcinoma (RCC) with heterotopic formation has been reported very rarely. We report this rare entity in a 33-year-old female patient who came to the out-patient department after complaining of pain in the lumbar region of the left side for 2 years. A computed tomography scan showed a heterogeneously enhancing lesion originating from the posterior cortex of the left kidney in the upper pole. It had many chunky calcification foci and was treated with left robotic partial nephrectomy. Histo-pathological examination revealed clear cell RCC with the heterotopic bone formation with a tumor size measuring 5 × 4 × 2.5 cm; the tumor was limited to the kidney, and the tumor resection margin were free of tumor, WHO/ISUP Grade 2. The pathological stage (AJCC 8th edition PTNM) was p T1b p NX p MX. The prognostic implications regarding calcification are poorly addressed in the literature. Patients suffering from osseous metaplasia are often in their early stages of the disease and have a favorable prognosis.
肾细胞癌（RCC）伴异位形成的情况非常罕见。我们报告了一位 33 岁女性患者的这种罕见病例，她因左侧腰部疼痛 2 年来门诊就诊。计算机断层扫描显示一个起源于左肾上极后皮质的不均匀增强病变。它有许多块状钙化灶，接受了左机器人部分肾切除术治疗。组织病理学检查显示伴异位骨形成的透明细胞 RCC，肿瘤大小为 5×4×2.5cm；肿瘤局限于肾脏，肿瘤切缘无肿瘤，WHO/ISUP 分级 2 级。病理分期（第 8 版 AJCC pT1b pNX pMX）为 pT1b。关于钙化的预后意义在文献中描述甚少。发生骨化生的患者通常处于疾病的早期阶段，预后良好。
