作用于P2X7受体的天然产物衍生化合物的综合综述：疾病中的潜在治疗药物
A comprehensive review of natural product-derived compounds acting on P2X7R: The promising therapeutic drugs in disorders.
作者信息
Liu Zhenling, Liu Wenjin, Han Mengyao, Wang Mingzhu, Li Yinchao, Yao Yongfang, Duan Yongtao
机构信息
Children's Hospital Affiliated to Zhengzhou University, Zhengzhou University, Zhengzhou 450018, China.
School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
出版信息
Phytomedicine. 2024 Jun;128:155334. doi: 10.1016/j.phymed.2023.155334. Epub 2023 Dec 31.
BACKGROUND
The P2X7 receptor (P2X7R) is known to play a significant role in regulating various pathological processes associated with immune regulation, neuroprotection, and inflammatory responses. It has emerged as a potential target for the treatment of diseases. In addition to chemically synthesized small molecule compounds, natural products have gained attention as an important source for discovering compounds that act on the P2X7R.
PURPOSE
To explore the research progress made in the field of natural product-derived compounds that act on the P2X7R.
METHODS
The methods employed in this review involved conducting a thorough search of databases, include PubMed, Web of Science and WIKTROP, to identify studies on natural product-derived compounds that interact with P2X7R. The selected studies were then analyzed to categorize the compounds based on their action on the receptor and to evaluate their therapeutic applications, chemical properties, and pharmacological actions.
RESULTS
The natural product-derived compounds acting on P2X7R can be classified into three categories: P2X7R antagonists, compounds inhibiting P2X7R expression, and compounds regulating the signaling pathway associated with P2X7R. Moreover, highlight the therapeutic applications, chemical properties and pharmacological actions of these compounds, and indicate areas that require further in-depth study. Finally, discuss the challenges of the natural products-derived compounds exploration, although utilizing compounds from natural products for new drug research offers unique advantages, problems related to solubility, content, and extraction processes still exist.
CONCLUSION
The detailed information in this review will facilitate further development of P2X7R antagonists and potential therapeutic strategies for P2X7R-associated disorders.
背景
已知P2X7受体（P2X7R）在调节与免疫调节、神经保护和炎症反应相关的各种病理过程中发挥重要作用。它已成为疾病治疗的潜在靶点。除了化学合成的小分子化合物外，天然产物作为发现作用于P2X7R的化合物的重要来源也受到了关注。
目的
探讨作用于P2X7R的天然产物衍生化合物领域的研究进展。
方法
本综述采用的方法包括全面检索数据库，包括PubMed、科学网和WIKTROP，以识别关于与P2X7R相互作用的天然产物衍生化合物的研究。然后对所选研究进行分析，根据化合物对受体的作用对其进行分类，并评估其治疗应用、化学性质和药理作用。
结果
作用于P2X7R的天然产物衍生化合物可分为三类：P2X7R拮抗剂、抑制P2X7R表达的化合物以及调节与P2X7R相关信号通路的化合物。此外，突出了这些化合物的治疗应用、化学性质和药理作用，并指出了需要进一步深入研究的领域。最后，讨论了天然产物衍生化合物探索的挑战，尽管利用天然产物中的化合物进行新药研究具有独特优势，但仍存在与溶解度、含量和提取过程相关的问题。
结论
本综述中的详细信息将有助于P2X7R拮抗剂的进一步开发以及针对P2X7R相关疾病的潜在治疗策略。
Zotero 插件