HLA-G 在肿瘤和 COVID-19 感染中的作用。

Role of HLA-G in tumors and upon COVID-19 infection.

机构信息

Institute of Translational Immunology, Medical School "Theodor Fontane", 14770, Brandenburg an der Havel, Germany; Medical Faculty, Martin Luther University Halle-Wittenberg, 06112, Halle (Saale), Germany; Fraunhofer Institute for Cell Therapy and Immunology, 04103, Leipzig, Germany.

出版信息

Hum Immunol. 2024 May;85(3):110792. doi: 10.1016/j.humimm.2024.110792. Epub 2024 Mar 29.

DOI:10.1016/j.humimm.2024.110792

PMID:38555250

Abstract

HLA-G expression of tumors and upon viral infections is involved in their immune escape leading to the evasion from both T and NK cell recognition. The underlying mechanisms of HLA-G expression in both pathophysiologic conditions are broad and range from genetic abnormalities to epigenetic, transcriptional and posttranscriptional regulation. This review summarizes the current knowledge of the frequency, regulation and clinical relevance of HLA-G expression upon neoplastic and viral transformation, its interaction with components of the microenvironment as well as its potential as diagnostic marker and/or therapeutic target. In addition, it discusses urgent topics, which have to be addressed in HLA-G research.

摘要

肿瘤和病毒感染时 HLA-G 的表达参与了它们的免疫逃逸，从而逃避了 T 细胞和 NK 细胞的识别。HLA-G 在这两种病理生理状态下的表达的潜在机制广泛，包括从遗传异常到表观遗传、转录和转录后调控。这篇综述总结了肿瘤和病毒转化时 HLA-G 表达的频率、调控和临床相关性、其与微环境成分的相互作用以及作为诊断标志物和/或治疗靶点的潜力。此外，它还讨论了 HLA-G 研究中需要解决的紧迫问题。