Kodentsova V M, Kosheleva O V, Vrzhesinskaya O A, Guseva G V, Zotov V A, Leonenko S N, Zhilinskaya N V
Siberian State Medical University, Ministry of Health of the Russian Federation, 634050, Tomsk, Russian Federation.
Vopr Pitan. 2024;93(1):72-79. doi: 10.33029/0042-8833-2024-93-1-72-79. Epub 2024 Jan 19.
Despite the widespread use of oat β-glucans as ingredient of foods and dietary supplements, there is insufficient data on their effect on the metabolism of vitamins and minerals. of the study was to evaluate the effect of including oat bran with a high content of β-glucans (β-glucan) in the diet on the absorption of micronutrients and lipid metabolism in growing rats deficient in vitamins D, group B and trace elements (iron, copper, zinc). . After the development of micronutrient deficiency (for 23 days), in order to assess the effect of oat bran (5%) with a high content of β-glucans on the correction of the micronutrient status of growing male Wistar rats (with initial body weight of 70.7±0.7 g), the missing micronutrients were introduced in the semi-synthetic diet deficient in vitamins D, group B, iron, copper and zinc within 7 days either along with β-glucan (1.47%) or without its addition. Indicators of micronutrient sufficiency (riboflavin serum concentration, daily urinary excretion of thiamine, riboflavin and 4-pyridoxic acid, measured by fluorometric methods; serum concentration and urinary excretion of calcium, magnesium, iron, zinc, copper, phosphorus, measured by the atomic absorption method or using standard methods on a biochemical analyzer) and the biochemical parameters of blood serum were compared with the parameters of rats adequately provided with all micronutrients throughout the experiment. . Replenishment of missing micronutrients in the diet of rats with deficiency in vitamins D and group B, iron, copper and zinc for 7 days led to the elimination of deficiency of vitamins B1, B2 and B6, regardless of the presence of β-glucans in the diet. At the same time, against the background of the presence of β-glucans in the feed, an increase in the absorption of iron was observed, as evidenced by an increase by 1.73 times in iron blood plasma level (р<0.05) and a tendency towards its urinary excretion decrease by 1.60 fold (р<0.10) compared to animals from the control group. Adding oat bran with β-glucans to the feed did not lead to a decrease in blood plasma level of total cholesterol and low-density lipoproteins cholesterol. The levels of high-density lipoprotein cholesterol and triglycerides in rats of all three groups did not have statistically significant differences. . The presence of β-glucans in the diet had virtually no effect on the absorption of B vitamins and improved the absorption of iron.
尽管燕麦β-葡聚糖作为食品和膳食补充剂的成分被广泛使用，但关于它们对维生素和矿物质代谢影响的数据并不充分。本研究的目的是评估在饮食中添加高含量β-葡聚糖（β-葡聚糖）的燕麦麸对维生素D、B族维生素和微量元素（铁、铜、锌）缺乏的生长大鼠微量营养素吸收和脂质代谢的影响。在微量营养素缺乏状态形成后（持续23天），为了评估高含量β-葡聚糖的燕麦麸（5%）对生长雄性Wistar大鼠（初始体重70.7±0.7克）微量营养素状态纠正的影响，在7天内将缺失的微量营养素添加到缺乏维生素D、B族维生素、铁、铜和锌的半合成饮食中，添加方式分为与β-葡聚糖（1.47%）一起添加或不添加β-葡聚糖。将微量营养素充足指标（通过荧光法测量的血清核黄素浓度、硫胺素、核黄素和4-吡哆酸的每日尿排泄量；通过原子吸收法或使用生化分析仪上的标准方法测量的血清钙、镁、铁、锌、铜、磷浓度和尿排泄量）以及血清生化参数与整个实验中所有微量营养素均充足供应的大鼠的参数进行比较。在维生素D、B族维生素、铁、铜和锌缺乏的大鼠饮食中补充缺失的微量营养素7天，无论饮食中是否存在β-葡聚糖，都导致维生素B1、B2和B6缺乏的消除。同时，在饲料中存在β-葡聚糖的背景下，观察到铁的吸收增加，血浆铁水平增加1.73倍（p<0.05）证明了这一点，与对照组动物相比，尿中铁排泄量有降低1.60倍的趋势（p<0.10）。在饲料中添加含β-葡聚糖的燕麦麸不会导致血浆总胆固醇和低密度脂蛋白胆固醇水平降低。三组大鼠的高密度脂蛋白胆固醇和甘油三酯水平没有统计学上的显著差异。饮食中β-葡聚糖的存在对B族维生素的吸收几乎没有影响，但改善了铁的吸收。
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