New Business Promotion Division, Nikoderm Research Inc.
Department of Applied Chemistry, Faculty of Science & Technology, Keio University.
J Oleo Sci. 2024;73(4):603-610. doi: 10.5650/jos.ess23224.
Factors affecting the in vitro Sun Protection Factor (SPF) and Ultraviolet-A Protection Factor (UVA-PF) of sunscreens were analyzed for verifying the validity and reliability of the ISO24443 evaluation method. UV absorbance measurements by different spectrophotometers did not lead to the large difference in in vitro SPF/UVA-PF, although the UV absorbance determined by each spectrophotometer exhibited relatively large difference when it was larger than 2. On the other hand, relatively large difference was found in in vitro SPF/UVA-PF by utilizing European Cosmetic and Perfumery Association (Colipa) 1994 or UV-solar simulated radiation (UV-SSR) for the spectral irradiance. Appropriateness of employing the coefficient of adjustment for the determination of in vitro UVA-PF was also found to be reexamined.
影响防晒霜体外防晒因子（SPF）和紫外线 A 防护因子（UVA-PF）的因素进行了分析，以验证 ISO24443 评估方法的有效性和可靠性。不同分光光度计的紫外线吸收测量并没有导致体外 SPF/UVA-PF 产生很大差异，尽管每个分光光度计测定的紫外线吸收值大于 2 时，其差异相对较大。另一方面，利用欧洲化妆品和香水协会（Colipa）1994 年或紫外线模拟太阳辐射（UV-SSR）进行光谱辐照度时，体外 SPF/UVA-PF 也存在较大差异。还发现，对于体外 UVA-PF 的测定，调整系数的使用是否合适也需要重新考虑。
