Department of Cardiology, Toranomon Hospital.
Department of Hematology, Toranomon Hospital.
Int Heart J. 2024;65(2):349-353. doi: 10.1536/ihj.23-355.
Tyrosine kinase inhibitors (TKIs) are essential drugs for chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia. Cardiovascular or arteriothrombotic adverse events have been reported in patients treated with TKIs. We report 3 cases of Ponatinib-related vasospastic angina, in which prophylactic administration of nitrates or calcium channel blockers was effective.
酪氨酸激酶抑制剂 (TKI) 是治疗慢性髓性白血病和费城染色体阳性急性淋巴细胞白血病的重要药物。接受 TKI 治疗的患者报告有心血管或动脉血栓不良事件。我们报告了 3 例与 Ponatinib 相关的血管痉挛性心绞痛病例，预防性给予硝酸盐或钙通道阻滞剂是有效的。
