Luan Xiaoyu, Chen Peng, Miao Longyu, Yuan Xinying, Yu Chaoqun, Di Guohu
School of Basic Medicine, Qingdao University, 308 Ningxia Road, Qingdao, 266071, China.
Institute of Stem Cell and Regenerative Medicine, School of Basic Medicine, Qingdao University, Qingdao, China.
Mol Cell Biochem. 2025 Jan;480(1):19-41. doi: 10.1007/s11010-024-04978-2. Epub 2024 Mar 31.
Ferroptosis is a newly discovered type of regulated cell death participated in multiple diseases. Different from other classical cell death programs such as necrosis and apoptosis, ferroptosis involving iron-catalyzed lipid peroxidation is characterized by Fe accumulation and mitochondria alterations. The phenomenon of oxidative stress following organ ischemia-reperfusion (I/R) has recently garnered attention for its connection to the onset of ferroptosis and subsequent reperfusion injuries. This article provides a comprehensive overview underlying the mechanisms of ferroptosis, with a further focus on the latest research progress regarding interference with ferroptotic pathways in organ I/R injuries, such as intestine, lung, heart, kidney, liver, and brain. Understanding the links between ferroptosis and I/R injury may inform potential therapeutic strategies and targeted agents.
铁死亡是一种新发现的参与多种疾病的程序性细胞死亡。与坏死和凋亡等其他经典细胞死亡程序不同，铁死亡涉及铁催化的脂质过氧化，其特征是铁积累和线粒体改变。器官缺血再灌注（I/R）后的氧化应激现象最近因其与铁死亡的发生及随后的再灌注损伤的关联而受到关注。本文全面概述了铁死亡的机制，并进一步聚焦于在肠道、肺、心脏、肾脏、肝脏和大脑等器官I/R损伤中干扰铁死亡途径的最新研究进展。了解铁死亡与I/R损伤之间的联系可能为潜在的治疗策略和靶向药物提供依据。
