American Samoa Government, Department of Public health, Pago Pago, American Samoa, USA.
Department of Basic Medical Sciences, School of Medicine and Health Sciences, University of Papua New Guinea, Port Moresby, Papua New Guinea.
Trop Med Int Health. 2024 Jun;29(6):447-453. doi: 10.1111/tmi.13988. Epub 2024 Mar 31.
Habitual betel quid chewing, a tobacco product, is a leading cause of oral cancer in Asia-Pacific countries where this practice is most prevalent. However, it is not well understood whether betel quid chewing is also a cause of adverse cardiovascular outcomes. To address this gap, we conducted a systematic literature review of peer-reviewed published studies evaluating the association between habitual betel quid use on the risk of adverse cardiovascular outcomes.
We searched PubMed for studies assessing the correlation between betel quid chewing and cardiovascular health. We included studies if (i) they included human subjects; (ii) were peer-reviewed articles in indexed journals; and (iii) were in English. We extracted data from eligible studies and stratified them by geographical location, study designs and cardiovascular outcomes. Finally, we did a narrative synthesis of the data to identify adverse cardiovascular outcomes associated with chronic betel quid use.
We reviewed data from 19 studies that met the inclusion criteria. Habitual betel quid chewing was associated with hypertension, atherosclerosis, inflammation and ischaemic heart disease. In addition, betel quid use was a risk factor for arrhythmias. Interestingly, betel quid use was an independent risk factor for cardiovascular disease in women. Long-term betel quid consumption was associated with higher risks for all-cause mortality and increased overall cardiovascular risk.
Habitual betel quid chewing is an important cardiovascular risk factor in populations where the practice is prevalent.
习惯性嚼槟榔，一种烟草制品，是亚太国家口腔癌的主要原因，这些国家是这种习惯最盛行的地区。然而，槟榔咀嚼是否也会导致不良心血管结局，这一点还不太清楚。为了解决这一差距，我们对评估习惯性嚼槟榔与不良心血管结局之间关联的同行评议已发表研究进行了系统文献回顾。
我们在 PubMed 上搜索了评估槟榔咀嚼与心血管健康相关性的研究。我们纳入了符合以下条件的研究：（i）纳入人类受试者；（ii）为索引期刊上的同行评议文章；（iii）为英文。我们从合格研究中提取数据，并按地理位置、研究设计和心血管结局对其进行分层。最后，我们对数据进行了叙述性综合分析，以确定与慢性嚼槟榔相关的不良心血管结局。
我们回顾了符合纳入标准的 19 项研究的数据。习惯性嚼槟榔与高血压、动脉粥样硬化、炎症和缺血性心脏病有关。此外，槟榔使用是心律失常的一个危险因素。有趣的是，槟榔使用是女性心血管疾病的一个独立危险因素。长期嚼槟榔与全因死亡率升高和整体心血管风险增加有关。
在嚼槟榔习惯流行的地区，习惯性嚼槟榔是一个重要的心血管危险因素。
