[囊性纤维化患儿营养状况与临床特征及肺功能的相关性]
[Correlation of nutritional status with clinical characteristics and lung function in children with cystic fibrosis].
作者信息
Li Dong-Dan, Shen Yue-Lin, Wang Mei-Chen, Yang Wen-Li, Xia Lu-Lu, Zhang Yu-Qing, Zhao Shun-Ying, Yan Jie
机构信息
Department of Nutrition, Beijing Children's Hospital,Capital Medical University/National Center for Children's Health, Beijing 100045, China.
出版信息
Zhongguo Dang Dai Er Ke Za Zhi. 2024 Mar 15;26(3):275-281. doi: 10.7499/j.issn.1008-8830.2308075.
OBJECTIVES
To investigate the nutritional status of children with cystic fibrosis (CF) and understand the correlation between malnutrition and clinical characteristics as well as lung function.
METHODS
A retrospective analysis was performed on clinical data of CF children admitted from January 2016 to June 2023. Clinical characteristics of CF children with different nutritional statuses were compared, and the correlation between malnutrition and lung function was analyzed.
RESULTS
A total of 52 CF children were included, comprising 25 boys (48%) and 27 girls (52%), aged between 7 months and 17 years. Respiratory symptoms were the predominant clinical manifestations (96%, 50/52). The prevalence of malnutrition was 65% (34/52), with moderate/severe malnutrition being the most common (65%, 22/34). The malnutrition group had a longer duration of illness, higher proportion of digestive system symptoms, and lower levels of serum albumin (<0.05). Pulmonary function parameters, including forced expiratory volume in one second as a percentage of the predicted value, ratio of forced expiratory volume in one second to forced vital capacity, forced expiratory flow at 25% of forced vital capacity exhaled, forced expiratory flow at 50% of forced vital capacity exhaled, forced expiratory flow at 75% of forced vital capacity exhaled, and maximum mid-expiratory flow as a percentage of the predicted value, were lower in the malnutrition group compared to the normal nutrition group (<0.05). Correlation analysis showed body mass index Z-score was positively correlated with the above six pulmonary function parameters (<0.05).
CONCLUSIONS
The prevalence of malnutrition is high in CF children and is associated with decreased lung function. CF children with higher body mass index have better lung function. Therefore, screening and evaluation of nutritional status as well as appropriate nutritional intervention should be emphasized in CF children.
目的
探讨囊性纤维化（CF）患儿的营养状况，了解营养不良与临床特征及肺功能之间的相关性。
方法
对2016年1月至2023年6月收治的CF患儿临床资料进行回顾性分析。比较不同营养状况CF患儿的临床特征，分析营养不良与肺功能的相关性。
结果
共纳入52例CF患儿，其中男25例（48%），女27例（52%），年龄7个月至17岁。呼吸道症状为主要临床表现（96%，50/52）。营养不良患病率为65%（34/52），以中度/重度营养不良最为常见（65%，22/34）。营养不良组病程更长，消化系统症状比例更高，血清白蛋白水平更低（<0.05）。与正常营养组相比，营养不良组的肺功能参数，包括一秒用力呼气容积占预计值百分比、一秒用力呼气容积与用力肺活量比值、呼出用力肺活量25%时的用力呼气流量、呼出用力肺活量50%时的用力呼气流量、呼出用力肺活量75%时的用力呼气流量以及最大呼气中期流量占预计值百分比均更低（<0.05）。相关性分析显示体重指数Z评分与上述六项肺功能参数呈正相关（<0.05）。
结论
CF患儿营养不良患病率高，且与肺功能下降有关。体重指数较高的CF患儿肺功能更好。因此，应重视CF患儿营养状况的筛查和评估以及适当的营养干预。
Zotero 插件