胃肠道急性移植物抗宿主病中短链脂肪酸的研究进展
Research advances on short-chain fatty acids in gastrointestinal acute graft--host disease.
作者信息
Song Xinping, Lao Jing, Wang Lulu, Liu Sixi
机构信息
Shenzhen Children's Hospital, China Medical University, Shenzhen, Guangdong 518026, China.
Department of Hematology and Oncology, Shenzhen Children's Hospital, 7019 Yitian Road, Futian District, Shenzhen, Guangdong 518026, China.
出版信息
Ther Adv Hematol. 2024 Mar 28;15:20406207241237602. doi: 10.1177/20406207241237602. eCollection 2024.
Gastrointestinal acute graft--host disease (GI-aGVHD) is a severe early complication following allogeneic hematopoietic stem cell transplantation (allo-HSCT). It has been shown that the intestinal microbiota plays a critical role in this process. As metabolites of the intestinal microbiota, short-chain fatty acids (SCFAs) are vital for maintaining the host-microbiota symbiotic equilibrium. This article provides an overview of the protective effect of SCFAs in the gastrointestinal tract, emphasizes their association with GI-aGVHD, and explores relevant research progress in prevention and treatment research.
胃肠道急性移植物抗宿主病（GI-aGVHD）是异基因造血干细胞移植（allo-HSCT）后严重的早期并发症。研究表明，肠道微生物群在这一过程中起关键作用。作为肠道微生物群的代谢产物，短链脂肪酸（SCFAs）对于维持宿主-微生物群共生平衡至关重要。本文综述了SCFAs在胃肠道中的保护作用，强调了它们与GI-aGVHD的关联，并探讨了预防和治疗研究中的相关进展。
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