Chikui Toru, Ohga Masahiro, Kami Yukiko, Togao Osamu, Kawano Shintaro, Kiyoshima Tamotsu, Yoshiura Kazunori
Section of Oral and Maxillofacial Radiology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
Department of Medical Technology, Kyushu University Hospital, Fukuoka, Japan.
Acta Radiol Open. 2024 Mar 28;13(3):20584601241244777. doi: 10.1177/20584601241244777. eCollection 2024 Mar.
Diffusion-weighted imaging (DWI) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) are widely used in the orofacial region. Furthermore, quantitative analyses have proven useful. However, a few reports have described the correlation between DWI-derived parameters and DCE-MRI-derived parameters, and the results have been controversial.
To evaluate the correlation among parameters obtained by DWI and DCE-MRI and to compare them between benign and malignant lesions.
Fifty orofacial lesions were analysed. The apparent diffusion coefficient (ADC), true diffusion coefficient (D), pseudodiffusion coefficient (D*) and perfusion fraction (f) were estimated by DWI. For DCE-MRI, TK model analysis was performed to estimate physiological parameters, for example, the influx forward volume transfer constant into the extracellular-extravascular space (EES) (K) and fractional volumes of EES and plasma components (ve and vp).
Both ADC and D showed a moderate positive correlation with ve (ρ = 0.640 and 0.645, respectively). K showed a marginally weak correlation with f (ρ = 0.296), while vp was not correlated with f or D*; therefore, IVIM perfusion-related parameters and TK model perfusion-related parameters were not straightforward. Both D and ve yielded high diagnostic power between benign lesions and malignant tumours with areas under the curve (AUCs) of 0.830 and 0.782, respectively.
Both D and ve were reliable parameters that were useful for the differential diagnosis. In addition, the true diffusion coefficient (D) was affected by the fractional volume of EES.
扩散加权成像（DWI）和动态对比增强磁共振成像（DCE-MRI）在口腔颌面部区域广泛应用。此外，定量分析已证明是有用的。然而，少数报告描述了DWI衍生参数与DCE-MRI衍生参数之间的相关性，结果存在争议。
评估DWI和DCE-MRI获得的参数之间的相关性，并比较良性和恶性病变之间的这些参数。
分析50例口腔颌面部病变。通过DWI估计表观扩散系数（ADC）、真实扩散系数（D）、伪扩散系数（D*）和灌注分数（f）。对于DCE-MRI，进行TK模型分析以估计生理参数，例如进入细胞外-血管外间隙（EES）的流入前向体积转移常数（K）以及EES和血浆成分的分数体积（ve和vp）。
ADC和D均与ve呈中度正相关（分别为ρ = 0.640和0.645）。K与f呈微弱相关（ρ = 0.296），而vp与f或D*无相关性；因此，体素内不相干运动（IVIM）灌注相关参数和TK模型灌注相关参数并不直接相关。D和ve在良性病变和恶性肿瘤之间均具有较高的诊断效能，曲线下面积（AUC）分别为0.830和0.782。
D和ve均为可靠参数，有助于鉴别诊断。此外，真实扩散系数（D）受EES分数体积的影响。
