J. Presl. 精油及其主要成分（）-肉桂醛基于酶的抗病毒潜力
Enzyme-Based Antiviral Potential of J. Presl. Essential Oil and Its Major Component ()-Cinnamaldehyde.
作者信息
Karadağ Ayşe Esra, Biltekin Sevde Nur, Ghani Usman, Demirci Betül, Demirci Fatih
机构信息
Department of Pharmacognosy, School of Pharmacy, Istanbul Medipol University, 34810 Beykoz, Istanbul, Turkey.
Department of Pharmaceutical Microbiology, School of Pharmacy, Istanbul Medipol University, 34810 Beykoz, Istanbul, Turkey.
出版信息
ACS Omega. 2024 Mar 13;9(12):14118-14122. doi: 10.1021/acsomega.3c09595. eCollection 2024 Mar 26.
In the present study, J. Presl. bark essential oil and its main component cinnamaldehyde was evaluated for neuraminidase (NA), transmembrane serine protease (TMPRSS2), and angiotensin converting enzyme 2 (ACE2) inhibitory activities. The chemical composition of essential oil was confirmed by both gas chromatography-mass spectrometry (GC/MS), and gas chromatography-flame ionization detection (GC-FID), where 75.9% ()-cinnamaldehyde was the major component. The ACE2, NA, and TMPRSS2 enzyme inhibitions of bark essential oil at 20 μg/mL concentration, and ()-cinnamaldehyde (5 μg/mL) were calculated and compared in the range of 54.2-89.9%. Molecular docking results supported that ()-cinnam-aldehyde was specific to ACE2 with 89.9% inhibition. Our findings suggest further studies to confirm the effective and safe use of the essential oil as well as the ()-cinnamaldehyde.
在本研究中，对J. Presl.树皮精油及其主要成分肉桂醛的神经氨酸酶（NA）、跨膜丝氨酸蛋白酶（TMPRSS2）和血管紧张素转换酶2（ACE2）抑制活性进行了评估。通过气相色谱-质谱联用（GC/MS）和气相色谱-火焰离子化检测（GC-FID）确定了精油的化学成分，其中75.9%的（）-肉桂醛是主要成分。计算并比较了树皮精油在20μg/mL浓度下以及（）-肉桂醛（5μg/mL）对ACE2、NA和TMPRSS2酶的抑制作用，抑制率范围为54.2-89.9%。分子对接结果表明，（）-肉桂醛对ACE2具有特异性抑制作用，抑制率为89.9%。我们的研究结果表明，需要进一步研究以确认该精油以及（）-肉桂醛的有效和安全用途。
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