不同薰衣草精油及其主要成分芳樟醇和樟脑对血管紧张素转换酶2（ACE2）和赖氨氧化酶（LOX）的抑制作用
ACE2 and LOX Enzyme Inhibitions of Different Lavender Essential Oils and Major Components Linalool and Camphor.
作者信息
Biltekin Sevde Nur, Karadaǧ Ayşe Esra, Demirci Betül, Demirci Fatih
机构信息
Department of Pharmaceutical Microbiology, School of Pharmacy, Istanbul Medipol University, Beykoz, Istanbul 34810, Turkey.
Institute of Sciences, Istanbul University, Istanbul 34116, Turkey.
出版信息
ACS Omega. 2022 Oct 5;7(41):36561-36566. doi: 10.1021/acsomega.2c04518. eCollection 2022 Oct 18.
In this present study, , , and essential oils and their main compounds linalool and camphor were evaluated for lipoxygenase enzyme (LOX) and for angiotensin converting enzyme 2 (ACE2) inhibition potential. The chemical compositions of , , and essential oils were confirmed both by gas chromatography-mass spectrometry and gas chromatography-flame ionization detection, where 22.4, 0.9, and 30.6% linalool and 17.8, 54.7, and 15% camphor were identified for each oil among other components, respectively. Enzyme inhibitory activity studies were performed at 20 μg/mL for the tested essential oils, whereas for linalool and camphor concentrations, 5 μg/mL was used. The ACE2 inhibitions of , , and essential oils were 25.4, 34.1, and 27.1%, while the LOX inhibitions were observed as 79, 49.1, and 86.7%, respectively. In addition, linalool and camphor showed remarkable ACE2 inhibition with 77.1 and 85.1%, whereas the LOX inhibition was observed at 92 and 67.2%, respectively. In conclusion of the initial findings, further detailed studies are needed to confirm the safe use.
在本研究中，对[具体植物1]、[具体植物2]和[具体植物3]的精油及其主要成分芳樟醇和樟脑进行了脂氧合酶（LOX）和血管紧张素转换酶2（ACE2）抑制潜力的评估。通过气相色谱 - 质谱联用和气相色谱 - 火焰离子化检测确定了[具体植物1]、[具体植物2]和[具体植物3]精油的化学成分，在每种精油的其他成分中，分别鉴定出22.4%、0.9%和30.6%的芳樟醇以及17.8%、54.7%和15%的樟脑。对测试的精油在20μg/mL浓度下进行酶抑制活性研究，而对于芳樟醇和樟脑，使用的浓度为5μg/mL。[具体植物1]、[具体植物2]和[具体植物3]精油对ACE2的抑制率分别为25.4%、34.1%和27.1%，而对LOX的抑制率分别为79%、49.1%和86.7%。此外，芳樟醇和樟脑对ACE2的抑制率分别为77.1%和85.1%，而对LOX的抑制率分别为92%和67.2%。根据初步研究结果，需要进一步详细研究以确认其安全使用性。
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