Al-Ibraheem Akram, Abdlkadir Ahmed Saad, Al-Hajaj Nabeela, Khalaf Aysar, Salah Samer
Department of Nuclear Medicine, King Hussein Cancer Center (KHCC), Amman, Jordan.
Warith International Cancer Institute, Karbala, Iraq.
Acta Radiol Open. 2024 Mar 28;13(2):20584601241240318. doi: 10.1177/20584601241240318. eCollection 2024 Feb.
Gallium-PSMA positron emission tomography/computer tomography has been utilized recently for the diagnosis and staging of prostate cancer. PSMA is a transmembrane protein that is expressed not only in the prostate gland but also in other tissues. While some pitfalls have been addressed, there are still uncertainties. Herein, we report a 79-year-old male with prostate cancer who underwent a PSMA scan after coronary artery bypass graft surgery, revealing disease progression and PSMA-avid foci at the surgical stitch sites. This report discusses the immunohistochemical and molecular imaging mechanisms underlying PSMA expression in surgical scar tissues, providing critical insights for optimizing radiologic reporting in such situations.
镓-前列腺特异性膜抗原正电子发射断层扫描/计算机断层扫描最近已被用于前列腺癌的诊断和分期。前列腺特异性膜抗原是一种跨膜蛋白，不仅在前列腺中表达，也在其他组织中表达。虽然一些问题已经得到解决，但仍存在不确定性。在此，我们报告一名79岁的前列腺癌男性患者，他在冠状动脉搭桥手术后接受了前列腺特异性膜抗原扫描，结果显示疾病进展以及手术缝线部位有前列腺特异性膜抗原摄取灶。本报告讨论了手术瘢痕组织中前列腺特异性膜抗原表达的免疫组化和分子成像机制，为优化此类情况下的放射学报告提供了关键见解。
