冠状病毒疫苗接种对癫痫患者癫痫发作的影响。
The effect of the coronavirus vaccinations on seizures in patients with epilepsy.
作者信息
Delil Memet Sakir, Turk Bengi Gul, Kochan-Kizilkilic Esra, Abbaszade Hikmet, Yeni Seher Naz, Ozkara Cigdem
机构信息
Department of Neurology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Department of Neurology, Okmeydanı Training and Research Hospital, Istanbul, Turkey.
出版信息
Heliyon. 2024 Mar 18;10(6):e28337. doi: 10.1016/j.heliyon.2024.e28337. eCollection 2024 Mar 30.
PURPOSE
Information on COVID-19 vaccine tolerance and complications in patients with epilepsy is not yet sufficient to provide a recommendation for vaccination guidelines. The aim of this study was to investigate the effect of two types of COVID vaccines currently used in Turkey (mRNA vaccine from Pfizer/BioNTech and inactivated vaccine from Sinovac) on epileptic seizures.
METHODS
We included 318 patients with epilepsy who were admitted to our epilepsy outpatient clinic. Clinical characteristics such as age, gender, age at seizure onset and the duration of epilepsy were noted. Types and the numbers of the anti-seizure drugs were recorded. Patients were evaluated either by face-to-face or by teleconference interviews. The seizure frequency in the first thirty days after any dose of vaccination was questioned.
RESULTS
A total of 318 patients (149 females, 46.8%) with a confirmed diagnosis of epilepsy were enrolled in the study. An increase in seizure frequency was reported after the COVID-19 vaccine in 19 patients. Of these 19 patients, 2 were vaccinated with Sinovac, while 17 were vaccinated with BioNTech/Pfizer mRNA vaccine. There was no significant relationship between age, age at seizure onset, duration of epilepsy, type of seizures, seizure frequency or seizure induction. Status epilepticus was not reported in any of the participants.
CONCLUSION
Physicians need strong scientific evidence to advocate the importance of vaccine for COVID-19, that's why accumulation of knowledge related to this issue is important not only from medical but also from medico-legal point of interest. We aimed to contribute the current literature with our study to strengthen the physicians' hand while recommending COVID vaccines to PWE. Our results show that there is no significant increase in the risk of triggering seizures with COVID-19 vaccines. These data show that vaccination against COVID-19 with both vaccine types in patients with epilepsy is safe and well tolerated.
目的
关于新冠病毒疫苗在癫痫患者中的耐受性和并发症的信息，尚不足以提供疫苗接种指南的建议。本研究的目的是调查土耳其目前使用的两种新冠病毒疫苗（辉瑞/生物新技术公司的信使核糖核酸疫苗和科兴公司的灭活疫苗）对癫痫发作的影响。
方法
我们纳入了318名到我们癫痫门诊就诊的癫痫患者。记录了年龄、性别、癫痫发作起始年龄和癫痫病程等临床特征。记录了抗癫痫药物的种类和数量。通过面对面或电话会议访谈对患者进行评估。询问了接种任何一剂疫苗后前30天内的癫痫发作频率。
结果
共有318名确诊癫痫的患者（149名女性，占46.8%）纳入本研究。19名患者报告在接种新冠病毒疫苗后癫痫发作频率增加。在这19名患者中，2名接种了科兴疫苗，17名接种了辉瑞/生物新技术公司的信使核糖核酸疫苗。年龄、癫痫发作起始年龄、癫痫病程、癫痫发作类型、癫痫发作频率或癫痫诱发之间均无显著关联。所有参与者均未报告癫痫持续状态。
结论
医生需要有力的科学证据来倡导新冠病毒疫苗接种的重要性，这就是为什么不仅从医学角度，而且从法医学角度积累与这个问题相关的知识都很重要。我们旨在通过本研究为当前文献做出贡献，以在向癫痫患者推荐新冠病毒疫苗时增强医生的底气。我们的结果表明，新冠病毒疫苗引发癫痫发作的风险没有显著增加。这些数据表明，癫痫患者接种这两种类型的新冠病毒疫苗都是安全的，耐受性良好。
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