Division of Rehabilitation Medicine, Kobe University Hospital, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 651-0017, Japan.
Division of Rehabilitation Medicine, Tokushima University Hospital, 2-50-1 Kuramoto-cho, Tokushima, 770-8503, Japan.
Hematol Oncol Stem Cell Ther. 2024 Mar 22;17(2):146-153. doi: 10.56875/2589-0646.1120.
BACKGROUND/OBJECTIVE: The level of physical activity in the daily lives of cancer survivors following hematopoietic stem cell transplantation (HSCT) is crucial for maintaining their physical and mental health. Considering that life space mobility (LSM) may limit physical activity, maintaining and expanding LSM is particularly essential for post-HSCT survivors. This study aimed to identify factors influencing LSM in post-HSCT survivors.
Thirty cancer survivors after HSCT (14 women, mean age 52.0 ± 12.3 years, 196-3017 days post-HSCT) were included in this cross-sectional study. The assessment encompassed patient characteristics, employment status, life space (Life Space Assessment; LSA), physical function (handgrip strength, isometric knee extension strength, 5 chair standing test, walking speed), depression (Self-rating Depression Scale; SDS), fatigue (Cancer Fatigue Scale), and neighborhood walkability (Walk Score). The association between LSA and each factor was compared by correlation analysis. Subsequently, multiple regression analysis was conducted, with LSA as the dependent variable and independent variables being outcome measures exhibiting a significant correlation with LSA.
Variables significantly correlated with LSA included SDS (r =-0.65, p < .01), employment status (r=-0.60, p < .01), handgrip strength (r = 0.43, p = .02), and isometric knee extension strength (r = 0.40, p = .03). Results of multiple regression analysis show that SDS (β = -0.53, p < .01), employment status (β = 0.48, p < .01), and isometric knee extension strength (β = 0.27, p = .02) were significantly associated with LSA (R = 0.74).
Depression, employment status, and isometric knee extension strength were identified as factors related to LSM in post-HSCT survivors.
背景/目的：造血干细胞移植（HSCT）后癌症幸存者日常生活中的身体活动水平对于维持其身心健康至关重要。考虑到生活空间移动性（LSM）可能会限制身体活动，因此保持和扩大 LSM 对于 HSCT 后幸存者尤为重要。本研究旨在确定影响 HSCT 后幸存者 LSM 的因素。
本横断面研究纳入了 30 名 HSCT 后的癌症幸存者（14 名女性，平均年龄 52.0±12.3 岁，HSCT 后 196-3017 天）。评估内容包括患者特征、就业状况、生活空间（生活空间评估；LSA）、身体功能（手握力、等长膝伸肌力、5 次椅子站立试验、步行速度）、抑郁（自评抑郁量表；SDS）、疲劳（癌症疲劳量表）和邻里可步行性（步行得分）。通过相关分析比较 LSA 与各因素之间的关系。随后，进行多元回归分析，以 LSA 为因变量，与 LSA 显著相关的指标作为自变量。
与 LSA 显著相关的变量包括 SDS（r=-0.65，p<.01）、就业状况（r=-0.60，p<.01）、手握力（r=0.43，p=0.02）和等长膝伸肌力（r=0.40，p=0.03）。多元回归分析结果显示，SDS（β=-0.53，p<.01）、就业状况（β=0.48，p<.01）和等长膝伸肌力（β=0.27，p=0.02）与 LSA 显著相关（R=0.74）。
抑郁、就业状况和等长膝伸肌力是与 HSCT 后幸存者 LSM 相关的因素。
