经导管治疗转外科主动脉瓣置换术患者的当代治疗结果。

Contemporary outcomes of surgical aortic valve replacement in patients referred for a transcatheter approach.

机构信息

Meijer Heart and Vascular Institute, Division of Cardiothoracic Surgery, Corewell Health West, Grand Rapids, MI, United States of America; College of Human Medicine, Michigan State University, Grand Rapids, MI, United States of America.

College of Human Medicine, Michigan State University, Grand Rapids, MI, United States of America.

出版信息

Int J Cardiol. 2024 Jul 15;407:132004. doi: 10.1016/j.ijcard.2024.132004. Epub 2024 Mar 30.

Abstract

OBJECTIVES

The purpose of this study is to examine which patients referred to our structural valve clinic for potential transcatheter aortic valve replacement (TAVR) are receiving surgical aortic valve replacement (SAVR) whether due to unsuitable anatomy for TAVR versus other reasons.

METHODS

Individuals referred for TAVR from January 2019 to March 2022, who ultimately underwent SAVR were examined, retrospectively. Patients were divided into 2 surgical groups: TAVR was technically unsuitable (SAVR-TU) and those in which TAVR was technically feasible (SAVR-TF).

RESULTS

215 patients referred for TAVR underwent SAVR with 61 (28.4%) patients in the SAVR-TU group and 154 (71.6%) in the SAVR-TF group. The SAVR-TU group were more commonly female (52.5% vs 23.4%, p < 0.0001), had a higher incidence of stroke at baseline (9.8% vs 2.0%, p = 0.017) were frailer (5-m gait 5.2 s vs 4.7 s, p = 0.0035), and had a higher Society of Thoracic Surgery risk score (2.2 vs 1.7, p = 0.04). In the SAVR-TU group, unsuitability for TAVR was due to inadequate aortic root anatomy (86.9%), and poor peripheral access (6.6%). In the SAVR-TF group, the most common reasons for SAVR referral were concomitant coronary artery disease (42.9%), bicuspid aortic valve disease (16.9%), and concomitant aortic aneurysm (10.4%). Overall, in-hospital mortality was 1.4% with no difference between both groups. One-year survival was 96.7%.

CONCLUSION

Despite a higher trend of aortic stenosis being treated with TAVR, higher risk patients unsuitable for TAVR can have SAVR with excellent outcomes. Moreover, patients with AS and concomitant other pathology should be evaluated for cardiac surgery.

摘要

目的

本研究旨在探讨因解剖结构不适宜行经导管主动脉瓣置换术(TAVR)而接受外科主动脉瓣置换术(SAVR)的患者,以及因其他原因而接受 SAVR 的患者。

方法

回顾性分析 2019 年 1 月至 2022 年 3 月间因 TAVR 而转诊至我院结构性瓣膜诊所、最终接受 SAVR 的患者。将患者分为 2 个外科组:TAVR 技术不适用(SAVR-TU)和 TAVR 技术可行(SAVR-TF)。

结果

215 例患者因 TAVR 而转诊,其中 61 例(28.4%)患者在 SAVR-TU 组,154 例(71.6%)患者在 SAVR-TF 组。SAVR-TU 组患者更常见于女性(52.5%比 23.4%,p<0.0001),基线时有更高的卒中发生率(9.8%比 2.0%,p=0.017),身体更虚弱(5 米步行速度 5.2s 比 4.7s,p=0.0035),并且胸外科医师学会风险评分更高(2.2 比 1.7,p=0.04)。在 SAVR-TU 组中,TAVR 不适用的原因是主动脉根部解剖结构不足(86.9%)和外周血管通路不良(6.6%)。在 SAVR-TF 组中,SAVR 转诊的最常见原因是同时合并冠状动脉疾病(42.9%)、二叶式主动脉瓣疾病(16.9%)和同时合并主动脉瘤(10.4%)。总体而言,住院死亡率为 1.4%,两组间无差异。1 年生存率为 96.7%。

结论

尽管经导管主动脉瓣置换术治疗主动脉瓣狭窄的趋势较高,但不适合行经导管主动脉瓣置换术的高危患者仍可接受外科主动脉瓣置换术,且预后良好。此外,患有主动脉瓣狭窄且同时合并其他病理学的患者应接受心脏手术评估。

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