糖皮质激素诱导的肾上腺功能不全和糖皮质激素撤药综合征：同一枚硬币的两面。
Glucocorticoid-induced adrenal insufficiency and glucocorticoid withdrawal syndrome: Two sides of the same coin.
机构信息
Department of Metabolism, Endocrinology & Diabetes, University of Michigan, Ann Arbor, MI; Assistant Professor, University of Michigan, Ann Arbor, MI
Department of Endocrinology, Diabetes, and Metabolism, Cleveland Clinic, Cleveland, OH; Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH.
出版信息
Cleve Clin J Med. 2024 Apr 1;91(4):245-255. doi: 10.3949/ccjm.91a.23039.
Diseases of the adrenal glands can lead to primary adrenal insufficiency, and suppression of the hypothalamic-pituitary-adrenal axis can cause secondary adrenal insufficiency (adrenal suppression). The most common cause of adrenal suppression is exogenous steroids, a condition recently termed (GIAI). Similarly, weaning from high doses of glucocorticoids or giving insufficient glucocorticoid replacement after curative surgery for endogenous hypercortisolism (Cushing syndrome) can lead to glucocorticoid withdrawal syndrome, which overlaps with GIAI.
肾上腺疾病可导致原发性肾上腺功能不全，而下丘脑-垂体-肾上腺轴抑制可导致继发性肾上腺功能不全（肾上腺抑制）。肾上腺抑制最常见的原因是外源性类固醇，这种情况最近被称为（GIAI）。同样，在内源性皮质醇过多症（库欣综合征）的治愈性手术后逐渐减少大剂量糖皮质激素或给予糖皮质激素替代不足，可导致糖皮质激素撤药综合征，与 GIAI 重叠。
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